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OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS IN PATIENTS WITH NONOCULAR BEHÇET DISEASE

Raafat, Karim, A., MD*; Allam, Riham S. H., M., MD, FRCS*; Medhat, Basma, M., MD

doi: 10.1097/IAE.0000000000002177
Original Study: PDF Only

Purpose: To describe the optical coherence tomography angiography findings in nonocular Behçet disease.

Methods: The superficial capillary plexus (SCP) and deep capillary plexus (DCP) and outer retinal and choroidal flow were evaluated using optical coherence tomography angiography. Perimetry was performed to correlate any microvascular and functional changes.

Results: Capillary nonperfusion areas were found in the superficial capillary plexus in 16/20 eyes (80%) and in the DCP in 17/20 eyes (85%). Perifoveal capillary arcade disruption and vessel rarefaction were present in both plexuses in all cases. Capillary telangiectasia was present in the superficial capillary plexus in five eyes (25%) and in the DCP in all eyes. Telangiectasia of the parafoveal capillaries was present in the DCP in all eyes. The mean area of the foveal avascular zone was not significantly different from that in 20 normal eyes (P = 0.68). However, mean and central subfield capillary density values were significantly lower (P < 0.001 and P < 0.005, respectively) in the Behçet disease group. Perimetry revealed central scotomata on the pattern deviation plot in 12 eyes (60%).

Conclusion: Telangiectasia of the parafoveal capillaries was detected in the DCP in all cases. Microvascular changes in the superficial capillary plexus and DCP in nonocular Behçet disease can be detected by optical coherence tomography angiography.

In this pilot study, 10 patients with nonocular Behçet disease were evaluated using optical coherence tomography angiography. Both superficial and deep capillary plexuses showed microvascular abnormalities (capillary nonperfusion areas, disruption of the perifoveal capillary arcade, vessel rarefaction, and capillary telangiectasia). Further research regarding the clinical significance of these findings is warranted.

Departments of *Ophthalmology, and

Rheumatology, Faculty of Medicine, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.

Reprint requests: Riham S. H. M. Allam, MD, FRCS, Department of Rheumatology, Faculty of Medicine, Kasr Al Ainy School of Medicine, Cairo University, 4 Omar Ebn Alkhattab Street, Dokki, Giza, Egypt 12311; e-mail: ryham_allam@yahoo.com

None of the authors has any financial/conflicting interests to disclose.

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© 2018 by Ophthalmic Communications Society, Inc.