Secondary Logo

Institutional members access full text with Ovid®


Milani, Paolo, MD*; Pellegrini, Marco, MD*,†; Massaccesi, Amedeo, MD*; Scotti, Fabrizio, MD*; Moschini, Stefania, MD*; Setaccioli, Marco, MD*; Secondi, Roberta, MD*; Bergamini, Fulvio, MD*

doi: 10.1097/IAE.0000000000002388
Original Study: PDF Only

Purpose: To describe the optical coherence tomography (OCT) angiography features of subretinal fibrosis in eyes with myopic choroidal neovascularization after natural evolution or secondary to intravitreal anti–vascular endothelial growth factor therapy.

Methods: Retrospective observational case series. All eyes underwent a multimodal imaging examination including fluorescein angiography, spectral domain OCT, OCT angiography, and en face OCT.

Results: Twenty-five eyes of 25 patients with mean age of 56.4 ± 14.9 were included in the study. Subretinal fibrosis was diagnosed at mean 30 (range 6–116) months before inclusion. Within the subretinal fibrosis, an abnormal vascular network was observed in 20/25 (80%) eyes, located typically in the outer retina (18/20, 90%) or the choriocapillaris (14/20, 70%) segmentation. The most prevalent patterns were “round tangle” and “tapered tangle.” On en face OCT, the subretinal fibrosis was evidenced in 24/25 (96%) eyes, most prevalently in the outer retina (21/25, 84%) and in the choriocapillaris (18/25, 72%), where main feature was white-hyperreflective (20/21, 95%) and dark-hyporeflective (17/18, 94%) appearance, respectively. The presence of subretinal fibrosis on en face OCT was positively correlated with the presence of abnormal vascular network on OCT angiography in 61% of the cases (P = 0.005).

Conclusion: Subretinal fibrosis secondary to myopic choroidal neovascularization frequently contains blood flow within a persistent abnormal vascular network as assessed by OCT angiography.

Subretinal fibrosis secondary to myopic choroidal neovascularization contains abnormal vascular network with blood flow as assessed by optical coherence tomography.

*Ophthalmology Department, IRCCS Istituto Auxologico Italiano, Milan, Italy; and

Department of Clinical Sciences, Eye Clinic, Luigi Sacco Hospital, University of Milan, Milan, Italy.

Reprint requests: Paolo Milani, MD, Istituto Auxologico Italiano, Via Mercalli 30, 20122, Milan, Italy; e-mail:

None of the authors has any financial/conflicting interests to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

© 2019 by Ophthalmic Communications Society, Inc.