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OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF SUBRETINAL FIBROSIS AFTER MYOPIC NEOVASCULARIZATION

Milani, Paolo, MD*; Pellegrini, Marco, MD*,†; Massaccesi, Amedeo, MD*; Scotti, Fabrizio, MD*; Moschini, Stefania, MD*; Setaccioli, Marco, MD*; Secondi, Roberta, MD*; Bergamini, Fulvio, MD*

doi: 10.1097/IAE.0000000000002388
Original Study: PDF Only

Purpose: To describe the optical coherence tomography (OCT) angiography features of subretinal fibrosis in eyes with myopic choroidal neovascularization after natural evolution or secondary to intravitreal anti–vascular endothelial growth factor therapy.

Methods: Retrospective observational case series. All eyes underwent a multimodal imaging examination including fluorescein angiography, spectral domain OCT, OCT angiography, and en face OCT.

Results: Twenty-five eyes of 25 patients with mean age of 56.4 ± 14.9 were included in the study. Subretinal fibrosis was diagnosed at mean 30 (range 6–116) months before inclusion. Within the subretinal fibrosis, an abnormal vascular network was observed in 20/25 (80%) eyes, located typically in the outer retina (18/20, 90%) or the choriocapillaris (14/20, 70%) segmentation. The most prevalent patterns were “round tangle” and “tapered tangle.” On en face OCT, the subretinal fibrosis was evidenced in 24/25 (96%) eyes, most prevalently in the outer retina (21/25, 84%) and in the choriocapillaris (18/25, 72%), where main feature was white-hyperreflective (20/21, 95%) and dark-hyporeflective (17/18, 94%) appearance, respectively. The presence of subretinal fibrosis on en face OCT was positively correlated with the presence of abnormal vascular network on OCT angiography in 61% of the cases (P = 0.005).

Conclusion: Subretinal fibrosis secondary to myopic choroidal neovascularization frequently contains blood flow within a persistent abnormal vascular network as assessed by OCT angiography.

Subretinal fibrosis secondary to myopic choroidal neovascularization contains abnormal vascular network with blood flow as assessed by optical coherence tomography.

*Ophthalmology Department, IRCCS Istituto Auxologico Italiano, Milan, Italy; and

Department of Clinical Sciences, Eye Clinic, Luigi Sacco Hospital, University of Milan, Milan, Italy.

Reprint requests: Paolo Milani, MD, Istituto Auxologico Italiano, Via Mercalli 30, 20122, Milan, Italy; e-mail: dottpaolomilani@hotmail.com

None of the authors has any financial/conflicting interests to disclose.

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© 2018 by Ophthalmic Communications Society, Inc.