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Peiretti, Enrico, MD*; Iovino, Claudio, MD*; Sacconi, Riccardo, MD; Caminiti, Giulia, MD*; Querques, Giuseppe, MD, PhD

doi: 10.1097/IAE.0000000000002234
Original Study: PDF Only

Purpose: To report diagnostic capability of optical coherence tomography angiography (OCTA) in detecting polypoidal choroidal vasculopathy and its morphologic characteristics in white patients with chronic central serous chorioretinopathy.

Methods: Retrospective consecutive series of 20 eyes (17 consecutive patients) with a diagnosis of polypoidal choroidal vasculopathy secondary to chronic central serous chorioretinopathy based on clinical and multimodal imaging were included. All patients underwent a complete ophthalmologic examination, including best-correct visual acuity, fundus autofluorescence, fluorescein and indocyanine green angiography, spectral-domain optical coherence tomography, and OCTA.

Results: In all eyes (100%), OCTA revealed the branching vascular network as a hyperflow lesion in both choriocapillaris and outer retina layers. Segmentation of the choriocapillaris in OCTA, in correspondence of the polypoidal dilation detected at indocyanine green angiography, showed a hyperflow round structure in 75% of cases and hypoflow round structure in 15%. Two of 20 eyes (10%) had no detectable polyps on OCTA.

Conclusion: Optical coherence tomography angiography is a noninvasive imaging modality allowing a good visualization of both branching vascular network and polyp dilations. Our findings suggest that OCTA is a useful tool in the investigation of chronic central serous chorioretinopathy complicated by polypoidal choroidal vasculopathy.

Polypoidal choroidal vasculopathy can occur in patients with chronic central serous chorioretinopathy. Optical coherence tomography angiography seems to be a valuable tool in detecting neovascular branching and aneurysmatic dilatations compared with multimodal imaging.

*Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy; and

Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy.

Reprint requests: Giuseppe Querques, MD, PhD, Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina 60, Milan 20132, Italy; e-mail:

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. The authors have no financial or proprietary interest in products, methods, or material used in this research.

© 2019 by Ophthalmic Communications Society, Inc.