To determine the sensitivity and specificity of different retinal imaging combinations for the diagnosis of choroidal neovascularization (CNV) in age-related macular degeneration.
Patients aged 50 years or older referred for suspicious recent-onset CNV related to age-related macular degeneration were prospectively included for 6 months. Data recorded included color fundus photographs (CFPs), spectral domain optical coherence tomography (SD-OCT), and fluorescein angiography (FA) images. Five retina specialists randomly interpreted SD-OCT combined with CFP, and then FA combined with CFP. The reference diagnosis of CNV was based on the agreement of two readers in the interpretation of the SD-OCT + FA + CFP combination.
One hundred and forty-eight patients (148 eyes) were included. For the diagnosis of CNV, the sensitivity of both SD-OCT + CFP and FA + CFP was of 90.9%. Type 2 CNV was diagnosed in 98% to 100% of cases with SD-OCT + CFP or FA + CFP, whereas Type 1 CNV was diagnosed in 82.9% of cases with SD-OCT + CFP and 81.6% with FA + CFP.
When used as a first diagnostic test, SD-OCT combined with CFP had sensitivity and specificity similar to those of FA combined with CFP, for the diagnosis of CNV in age-related macular degeneration. This shows the increasingly important role of SD-OCT as a first-line test in the diagnosis of CNV.
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In a prospective study, spectral domain optical coherence tomography and fluorescein angiography, combined with color fundus photograph used as a first diagnostic test in patients aged 50 years or older, had a similar sensitivity and specificity for the diagnosis of choroidal neovascularization in age-related macular degeneration.
*Ophthalmology Department, AP-HP, Hôpital Lariboisière, Université Paris Diderot, Sorbonne Paris Cité, France;
†Centre d'Imagerie et de Laser, Paris, France; and
‡Clinical Research Unit, AP-HP, Hôpital Lariboisière, Université Paris Diderot, Sorbonne Paris Cité, France.
Reprint requests: Ramin Tadayoni, MD, PhD, Lariboisière Hospital, 2 rue Ambroise Paré, 75010 Paris, France; e-mail: firstname.lastname@example.org
Public Financial Support: Département de la Recherche Clinique et du Développement (DRCD), AP-HP, Paris, France
None of the authors has any conflicting interests to disclose.