Institutional members access full text with Ovid®

Share this article on:

NOVEL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY BIOMARKER IN BRANCH RETINAL VEIN OCCLUSION MACULAR EDEMA

Yeung, Ling, MD*,‡; Wu, Wei-Chi, MD, PhD†,‡; Chuang, Lan-Hsin, MD*,‡; Wang, Nan-Kai, MD, PhD†,‡; Lai, Chi-Chun, MD†,‡

doi: 10.1097/IAE.0000000000002264
Original Study: PDF Only

Purpose: To evaluate the association between deep–superficial flow ratio (DSFR) and the treatment response of macular edema in branch retinal vein occlusion.

Methods: Thirty eyes from 30 patients with branch retinal vein occlusion who had received optical coherence tomography angiography examination were included. Seventeen normal fellow eyes acted as the control group. Patients were classified into the “good response group” and the “refractory group” by absence or presence of macular edema after 6 months of treatment. The DSFRs were calculated by dividing deep capillary plexus vessel density by superficial capillary plexus vessel density on optical coherence tomography angiography.

Results: The DSFR was 1.00 (SD ± 0.05) over parafoveal area in the control group. Among branch retinal vein occlusion eyes, parafoveal DSFR remained stable in the good response group (P = 0.822) and significantly decreased in the refractory group (P = 0.002). The DSFRs in the most severe nonperfusion area were significantly lower in the refractory group than in the good response group (0.85 ± 0.13 vs. 1.01 ± 0.15, P = 0.004). The DSFR in the most severe nonperfusion area was associates with treatment response in multivariate logistic regression (P = 0.015).

Conclusion: Deep–superficial flow ratio can represent the relative damage of deep capillary plexus to superficial capillary plexus. Decreased DSFR was found in branch retinal vein occlusion eyes with refractory macular edema.

The ratio of vessels in deep capillary plexus and superficial capillary plexus, i.e., deep–superficial flow ratio, was consistent over the parafoveal region in optical coherence tomography angiography of normal eyes. Reduction of deep–superficial flow ratio was found in branch retinal vein occlusion eyes with refractory macular edema.

*Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan;

Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; and

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Reprint requests: Chi-Chun Lai, MD, Department of Ophthalmology, Chang Gung Memorial Hospital, No. 5, Fu-Shin Street, Kweishan, Taoyuan 333, Taiwan; e-mail: chichun.lai@gmail.com

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.