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LONG-TERM VISUAL CHANGES IN INITIALLY STRONGER FELLOW EYES IN PATIENTS WITH UNILATERAL TYPE 3 NEOVASCULARIZATION

Kim, Jae Hui, MD*; Chang, Young Suk, MD; Kim, Jong Woo, MD*; Kim, Chul Gu, MD*; Lee, Dong Won, MD*; Kim, Hyoung Seok, MD*

doi: 10.1097/IAE.0000000000002239
Original Study: PDF Only

Purpose: To evaluate long-term visual changes in initially stronger fellow eyes in patients with unilateral Type 3 neovascularization.

Methods: This retrospective study included 102 patients who were newly diagnosed with unilateral Type 3 neovascularization and in whom the best-corrected visual acuity (BCVA) of the fellow eye was initially better than that of the involved eye. All patients were treated with intravitreal anti–vascular endothelial growth factor injections. The BCVAs were compared at diagnosis, 12 months, 24 months, and the final visit. In patients who experienced ≥3 lines of visual deterioration in the BCVA of the fellow eye, the reason for visual deterioration was also verified.

Results: The patients were followed for 45.9 ± 18.5 months after diagnosis. At diagnosis, the fellow-eye BCVA was better than that of the initially involved eye in all 102 patients. However, the fellow-eye visual acuity was the same or worse than that of the initially involved eye in 13 patients (12.7%) at 12 months, in 20 patients (19.6%) at 24 months, and in 24 patients (23.5%) at the final visit. At the final visit, 53 patients (51.9%) had experienced ≥3 lines of deterioration in the BCVA of the fellow eye. Fellow-eye neovascularization occurred in 42 patients, and geographic atrophy involving the fovea was noted in the remaining 11 patients.

Conclusion: Deterioration of the visual acuity of the fellow eye is frequently noted in unilateral Type 3 neovascularization. As a result of this deterioration, the initially stronger fellow eye did not remain stronger in 23.5% of the patients, suggesting the need for long-term strict treatment of the initially involved eye even when the visual acuity of the fellow eye is good.

During a mean 45.9-month follow-up period, 53 of the 102 patients (51.9%) with unilateral Type 3 neovascularization experienced ≥3 lines of deterioration in the visual acuity of the fellow eye. At the final visit, the initially stronger fellow eye was no longer the stronger eye in 24 patients (23.5%).

*Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, South Korea; and

Department of Ophthalmology, Konyang University College of Medicine, Daejeon, South Korea.

Reprint requests: Jae Hui Kim, MD, Department of Ophthalmology, Kim's Eye Hospital, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, Seoul 150-034, South Korea; e-mail: kimoph@gmail.com

Supported by Kim's Eye Hospital Research Center.

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.