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Technique and Outcome

Zhu, Xiaobo, MD, PhD*; Shen, Peiyang, MD, PhD; Li, Chu, MD*; Li, Han, MD*; Huang, Hao, MD*; Shi, Kangpei, MD*; Wang, Lei, MD*; Zhang, Xiaotong, MD*; Lu, Lin, MD, PhD*

doi: 10.1097/IAE.0000000000002145
Original Study: PDF Only

Purpose: To evaluate the effects of gas tamponade combined with laser photocoagulation without vitrectomy in patients with highly myopic foveoschisis.

Methods: This retrospective noncomparative case series included 30 eyes of 23 patients with highly myopic foveoschisis who were treated by intravitreal injection of 0.5 to 0.7 mL C3F8 combined with laser photocoagulation 1 week later, and remained in the face-down position for 3 weeks. The patients were followed up for at least 6 months after the treatment. The refractive status, best-corrected visual acuity, and anatomical parameters of retina observed with the optical coherence tomography before and after the treatment were recorded.

Results: The mean age of the 23 patients (6 men and 17 women) was 50.4 ± 15.1 years. The average follow-up duration was 20.8 ± 20.6 months. At the final follow-up, 23 eyes (76.7%) completely (17 eyes) or partially (6 eyes) resolved. Seventeen eyes had complete data of optical coherence tomography parameters, the mean central foveal thickness decreased significantly from 505.24 ± 466.22 μm to 186.41 ± 95.36 μm (P = 0.01), and the mean maximal macular thickness from 687.88 ± 397.00 μm to 313.65 ± 83.07 μm (P = 0.001). The mean final logarithm of the minimum angle of resolution best-corrected visual acuity (Snellen equivalent) of the 30 eyes ranged from 1.6 (20/800) to 0.2 (20/32), showing a slight improvement from 0.91 ± 0.44 (20/163) preoperatively to 0.90 ± 0.39 (20/160) postoperatively (P = 0.87).

Conclusion: C3F8 tamponade combined with laser photocoagulation could be an alternative treatment for highly myopic foveoschisis.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

This article documented the effects of intravitreal perfluoropropane (C3F8) injection combined with macular laser photocoagulation 1 week later for patients with highly myopic foveoschisis. This modified combined therapy can yield an acceptable success rate.

*Retina Division, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; and

Retina Department, Key Laboratory of Ophthalmology, Hainan Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, China.

Reprint requests: Lin Lu, MD, PhD, Retina Division, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54S Xianlie Road, Guangzhou 510060 China; e-mail:

Supported by Science and Technology Planning Project of Guangdong Province, China (2011B031800258).

None of the authors have any financial/conflicting interests to disclose.

© 2019 by Ophthalmic Communications Society, Inc.