To assess posterior segment findings on multicolor confocal scanning laser ophthalmoscopy by correlation with spectral domain optical coherence tomography (SD-OCT) and to quantify agreement between these imaging modalities.
Retrospective review of 159 eyes of 96 consecutive patients who underwent concurrent imaging with multicolor confocal scanning laser ophthalmoscopy and SD-OCT. Positive percent agreement and negative percent agreement were calculated for each finding identified on infrared, green, blue, and multicolor reflectance images using SD-OCT as a comparator.
Infrared reflectance best detected outer retinal and choroidal findings such as choroidal lesions, retinal pigment epithelium atrophy, peripapillary atrophy, and drusen (positive percent agreement 100, 92, 92, and 67%, respectively). Inner retinal changes including epiretinal membrane, lamellar macular hole, and inner retinal alterations were best detected on blue reflectance (positive percent agreement 94, 50, and 100%, respectively). Composite multicolor reflectance most effectively detected conditions with retinal elevation, including pigment epithelial detachment, intraretinal fluid, and subretinal fluid (positive percent agreement 65, 49, and 54%, respectively). Multicolor confocal scanning laser ophthalmoscopy detected intraretinal and subretinal hemorrhages, which were not detected on SD-OCT (negative percent agreement 87 and 97%, respectively).
Multicolor confocal scanning laser ophthalmoscopy is capable of identifying posterior segment pathology at various anatomical depths and may be a useful adjunct to SD-OCT for detecting or monitoring certain retinal conditions.
Multicolor confocal scanning laser ophthalmoscopy is capable of identifying posterior segment pathology at various anatomical depths and may be a useful adjunct to spectral domain optical coherence tomography for detecting or monitoring certain retinal conditions such as retinal hemorrhages, extent of epiretinal membrane formation, and aberrations in retinal contour.
*Duke Eye Center, Duke University, Durham, North Carolina;
†Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey;
‡Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio; and
§Byers Eye Institute, Stanford University, Palo Alto, California.
Reprint requests: Prithvi Mruthyunjaya, MD, Byers Eye Institute, Stanford, 2462 Watson Courtm, Palo Alto, NC 94303; e-mail: Prithvi9@Stanford.edu
S. Sharma—consultant: Allergan (non-relevant), S. Asrani—lecture honoraria from Heidelberg Engineering, P. Mruthyunjaya—consultant: Castle Biosciences, SPARK therapeutics, OPTOS Inc, Allergan (non-relevant). The remaining authors have no financial/conflicting interests to disclose.
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