Secondary Logo

Institutional members access full text with Ovid®

Share this article on:

FIXATION STATUS AFTER RESOLUTION OF MACULAR EDEMA ASSOCIATED WITH BRANCH RETINAL VEIN OCCLUSION

Kogo, Takahiro, MD; Muraoka, Yuki, MD, PhD; Ooto, Sotaro, MD, PhD; Suzuma, Kiyoshi, MD, PhD; Murakami, Tomoaki, MD, PhD; Iida, Yuto, MD; Iida-Miwa, Yuko, MD; Ghashut, Rima, MD; Miyata, Manabu, MD, PhD; Tsujikawa, Akitaka, MD, PhD

doi: 10.1097/IAE.0000000000002250
Original Study: PDF Only

Purpose: To evaluate fixation status of eyes with branch retinal vein occlusion (BRVO) and to investigate its association with other clinical parameters.

Methods: This study included 57 consecutive eyes with BRVO after resolution of macular edema. Fixation status was determined by microperimetry. Defect length of the foveal ellipsoid zone band was measured by optical coherence tomography, and retinal perfusion status was assessed by optical coherence tomography angiography.

Results: In microperimetry, the mean fixation rate around the gravitational center of all fixation points (defined as the fixation center) was found to be 79.8 ± 18.9%, which was significantly associated with defect length of the foveal ellipsoid zone band (P < 0.001) and distance between the foveal and fixation centers (P = 0.012). The integrity of the ellipsoid zone band at the fixation center was intact in 55 eyes (96.5%). Fixation centers were located within and outside the foveal avascular zone in 33 (57.9%) and 24 (42.1%) eyes, respectively; among the latter eyes, all fixation centers were perfused. Downward deviation of fixation points was rare, despite variations in the occluded area; there was a significant difference in distribution of deviation between eyes with superotemporal and inferotemporal BRVO (P < 0.001).

Conclusion: In eyes with BRVO, fixation status was strongly associated with visual acuity, morphologic damage, and retinal perfusion status both in the foveal area and at the fixation center after resolution of macular edema. This information regarding fixation status could facilitate vision management in patients with BRVO.

In eyes with branch retinal vein occlusion, fixation status was strongly associated with visual acuity, morphologic damage, and retinal perfusion status both in the foveal area and at the fixation center when the macular edema was resolved by anti–vascular endothelial growth factor treatment.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Reprint requests: Yuki Muraoka, MD, PhD, Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan; e-mail: muraoka@kuhp.kyoto-u.ac.jp

Supported in part by the Japan Society for the Promotion of Science (JSPS), Tokyo, Japan (Grant-in-Aid for Scientific Research, no. 21592256); Japan National Society for the Prevention of Blindness, Tokyo, Japan; Novartis Pharma K.K., Tokyo, Japan; and Innovative Techno-Hub for Integrated Medical Bio-Imaging of the Project for Developing Innovation Systems, from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

None of the authors has any financial/conflicting interests to disclose.

Conception and design of the study, Y. Muraoka; analysis and interpretation, T. Kogo, Y. Muraoka, and S. Ooto; writing of the article, T. Kogo and Y. Muraoka; critical revision of the article, S. Ooto, Y. Iida, Y. Iida-Miwa, K. Suzuma, T. Murakami, R. Ghashut, M. Miyata, and A. Tsujikawa; final approval of the article, T. Kogo, Y. Muraoka, S. Ooto, Y. Iida, Y. Iida-Miwa, K. Suzuma, T. Murakami, R. Ghashut, M. Miyata, and A. Tsujikawa; and data collection, K. Suzuma, Y. Muraoka, Y. Iida, and Y. Iida-Miwa.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.retinajournal.com).

© 2018 by Ophthalmic Communications Society, Inc.