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EVALUATION OF PATCHY ATROPHY SECONDARY TO HIGH MYOPIA BY SEMIAUTOMATED SOFTWARE FOR FUNDUS AUTOFLUORESCENCE ANALYSIS

Miere, Alexandra, MD*; Capuano, Vittorio, MD*; Serra, Rita, MD*,†; Jung, Camille, MD, PhD; Souied, Eric, MD, PhD*; Querques, Giuseppe, MD, PhD*,§

doi: 10.1097/IAE.0000000000001733
Original Study: PDF Only

Purpose: To evaluate the progression of patchy atrophy in high myopia using semiautomated software for fundus autofluorescence (FAF) analysis.

Methods: The medical records and multimodal imaging of 21 consecutive highly myopic patients with macular chorioretinal patchy atrophy (PA) were retrospectively analyzed. All patients underwent repeated fundus autofluorescence and spectral domain optical coherence tomography over at least 12 months. Color fundus photography was also performed in a subset of patients. Total atrophy area was measured on FAF images using Region Finder semiautomated software embedded in Spectralis (Heidelberg Engineering, Heidelberg, Germany) at baseline and during follow-up visits. Region Finder was compared with manually measured PA on FAF images.

Results: Twenty-two eyes of 21 patients (14 women, 7 men; mean age 62.8 + 13.0 years, range 32–84 years) were included. Mean PA area using Region Finder was 2.77 ± 2.91 SD mm2 at baseline, 3.12 ± 2.68 mm2 at Month 6, 3.43 ± 2.68 mm2 at Month 12, and 3.73 ± 2.74 mm2 at Month 18 (overall P < 0.005); this accounts for PA progression rate of 0.821 mm2/year. Atrophy progression was significantly greater among eyes with larger PA compared with smaller baseline PA at Months 6, 12, and 18. There was no statistically significant difference between semiautomated Region Finder PA area and manually measured PA area on FAF images.

Conclusion: Fundus autofluorescence analysis by Region Finder semiautomated software provides accurate measurements of lesion area and allows us to quantify the progression of PA in high myopia. In our series, PA enlarged significantly over at least 12 months, and its progression seemed to be related to the lesion size at baseline.

Evaluation of progression of patchy atrophy (PA) in high myopia using Region Finder, a semiautomated software for fundus autofluorescence analysis, revealed a significant enlargement of atrophic lesions over 12 months follow-up. Progression of PA seems to be influenced by the lesion size at baseline.

*Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, University Paris Est Créteil, Créteil, France;

Department of Ophthalmology, University of Cagliari, Cagliary, Italy;

Clinical Research Center and Biological Ressources Center, GRC Macula, Centre Hospitalier Intercommunal de Créteil, Créteil, France; and

§Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy.

Reprint requests: Giuseppe Querques, MD, PhD, Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, University Paris Est Créteil, Créteil 94010, France; e-mail: giuseppe.querques@hotmail.it

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.