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EFFECT OF OPTIC DISK—FOVEA DISTANCE ON MEASUREMENTS OF INDIVIDUAL MACULAR INTRARETINAL LAYERS IN NORMAL SUBJECTS

Qiu, Kunliang, MD*,†; Chen, Binyao, MD*; Chen, Haoyu, MD*; Gao, Enting, PhD; Yang, Jianling, MD*; Chen, Xinjian, PhD; Zhang, Mingzhi, MD*

doi: 10.1097/IAE.0000000000002043
Original Study: PDF Only

Purpose: To investigate the effect of optic disk—fovea distance (DFD) on measurements of macular intraretinal layers using spectral domain optical coherence tomography in normal subjects.

Methods: One hundred and eighty-two eyes from 182 normal subjects were imaged using spectral domain optical coherence tomography. The average thicknesses of eight macular intraretinal layers were measured using an automatic segmentation algorithm. Partial correlation test and multiple regression analysis were used to determine the effect of DFD on thicknesses of intraretinal layers.

Results: Disk—fovea distance correlated negatively with the overall average thickness in all the intraretinal layers (r ≤ −0.17, all P ≤ 0.025) except the ganglion cell layer and photoreceptor. In multiple regression analysis, greater DFD was associated with thinner nerve fiber layer (6.78 μm decrease per each millimeter increase in DFD, P < 0.001), thinner ganglion cell—inner plexiform layer (2.16 μm decrease per each millimeter increase in DFD, P = 0.039), thinner ganglion cell complex (8.94 μm decrease per each millimeter increase in DFD, P < 0.001), thinner central macular thickness (18.16 μm decrease per each millimeter increase in DFD, P < 0.001), and thinner total macular thickness (15.94 μm decrease per each millimeter increase in DFD, P < 0.001).

Conclusion: Thinner measurements of macular intraretinal layers were significantly associated with greater DFD. A clinical assessment of macular intraretinal layers in the evaluation of various macular diseases should always be interpreted in the context of DFD.

Thinner measurements of macular intraretinal layers were significantly associated with greater optic disk—fovea distance. A clinical assessment of thickness measurements of macular intraretinal layers in the evaluation of various retina diseases involving macular changes should take into consideration of optic disk—fovea distance.

*Joint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, People's Republic of China;

Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; and

School of Electronics and Information Engineering, Soochow University, Suzhou, People's Republic of China.

Reprint requests: Mingzhi Zhang, MD, Joint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Dongxia Road, Shantou, Guangdong Province, 515041 People's Republic of China; e-mail: zmz@jsiec.org

Supported by Grant No. 81486126, from the National Nature Science Foundation of China; by Grant No. 2014KQNCX075, from Foundation for Distinguished Young Talents in Higher Education of Guangdong, China; and by the University of Groningen Abel Tasman Talent Program (University Medical Center Groningen/Shantou University Medical College). The funding organizations had no role in the design, conduct, analysis, or publication of this research.

None of the authors has any conflicting interests to disclose.

X. Chen and M. Zhang contributed equally.

Involved in study design and conduct (M.Z., X.C., and H.C.); data collection, management, and analysis (K.Q., B.C., E.G., and J.Y.), and interpretation (M.Z and K.Q.); and manuscript preparation, review, or approval (M.Z, X.C., H.C., and K.Q.).

© 2018 by Ophthalmic Communications Society, Inc.