Share this article on:

CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA

Egawa, Mariko, MD, PhD*,†; Mitamura, Yoshinori, MD, PhD*,†; Niki, Masanori, MD*,†; Sano, Hiroki, MD*,†; Miura, Gen, MD, PhD; Chiba, Akihiro, MD; Yamamoto, Shuichi, MD, PhD; Sonoda, Shozo, MD, PhD†,§; Sakamoto, Taiji, MD, PhD†,§

doi: 10.1097/IAE.0000000000002285
Original Study: PDF Only

Purpose: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions.

Methods: The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length–matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer.

Results: In the inner choroid, the luminal area and the ratio of luminal/total choroidal area (L/C ratio) were significantly smaller in RP than in controls (P = 0.010, P < 0.001, respectively), whereas the stromal area was not significantly different (P = 0.114). The inner choroidal L/C ratio was significantly correlated with the best-corrected visual acuity, mean deviation, foveal sensitivity, width of the ellipsoid zone, and central foveal thickness in RP after adjusting for the axial length, age, and sex (all P < 0.005).

Conclusion: The significant correlations between the inner choroidal structures and the visual functions and retinal structures indicate that the choroidal structures are altered in association with the progression of RP.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

We report the structural changes in the inner and outer choroid determined by the binarization of enhanced depth imaging optical coherence tomographic images in 100 eyes with retinitis pigmentosa compared with 60 normal controls and significant correlations between the inner choroidal structures and visual functions in the eyes with retinitis pigmentosa.

*Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan;

Japan Clinical Retina Study Group (J-CREST Group), Kagoshima, Japan;

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan; and

§Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Reprint requests: Yoshinori Mitamura, MD, PhD, Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan; e-mail: ymitaymitaymita@yahoo.co.jp

Supported in part by grant-in-aid 16K11288 (to Y.M.) from the Ministry of Education, Science, Sports and Culture, Japan.

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.