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CORRELATIONS BETWEEN CHANGES IN PHOTORECEPTOR LAYER AND OTHER CLINICAL CHARACTERISTICS IN CENTRAL SEROUS CHORIORETINOPATHY

Yu, Jia, MD*,†; Jiang, Chunhui, MD, PhD*,†,‡; Xu, Gezhi, MD, PhD*,†

doi: 10.1097/IAE.0000000000002092
Original Study: PDF Only

Purpose: To clarify the correlations between changes in the photoreceptor layer (PRL) and other clinical characteristics during central serous chorioretinopathy.

Methods: Patients with central serous chorioretinopathy with one eye affected were enrolled. Photoreceptor layer appearance within the detached area was evaluated, and its correlations with symptom duration, best-corrected visual acuity, and the difference in the foveal outer nuclear layer thickness between the affected and contralateral eyes were analyzed.

Results: A total of 222 patients were included. The PRL outer border appeared either smooth, granulated, or as scattered dots attached to external limiting membrane. These different appearances were associated with elongation in symptom duration (18, 180, and 1,855 days), decreases in best-corrected visual acuity (6/10, 6/15, and 6/120), and increases in the difference of foveal outer nuclear layer thickness (−16, −32, and −60 μm). Among eyes with smooth PRL outer border, which had similar symptom duration, eyes with foveal PRL defect had poorer best-corrected visual acuity and greater reduction in outer nuclear layer thickness than the other eyes (all P = 0.00).

Conclusion: Morphologic changes in PRL, best-corrected visual acuity, the reduction in foveal outer nuclear layer thickness, and symptom duration correlate closely but may behave asynchronously. These objective parameters, besides symptom duration, could be helpful when considering the timing of central serous chorioretinopathy treatment.

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*Department of Ophthalmology, Eye & Ear Nose Throat Hospital of Fudan University, Shanghai, China;

Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China; and

Key Laboratory of Myopia of the State Health Ministry, Shanghai, China.

Reprint requests: Chunhui Jiang, MD, PhD, Department of Ophthalmology, Eye & Ear Nose Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China; e-mail: chhjiang70@163.com

Supported by National Key Basic Research Program of China (Grant no. 2013CB967503), the National Major Scientific Equipment Program (Grant no. 2012YQ12008003), the Science and Technology Commission of Shanghai Municipality (Grant no. 15DZ1942204 and 16140901000), and Youth Project of Shanghai Municipal Commission of Health and Family Planning (Grant no. 20164Y0061). The study was partially supported by the Shanghai Hospital Development Center (Grant no.SHDC12016116).

None of the authors has any conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.