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COMBINED VITRECTOMY WITH INTRAVITREAL DEXAMETHASONE IMPLANT FOR REFRACTORY MACULAR EDEMA SECONDARY TO DIABETIC RETINOPATHY, RETINAL VEIN OCCLUSION, AND NONINFECTIOUS POSTERIOR UVEITIS

Pang, John Paul, MD*,†; Son, Gisung, MD*; Yoon, Young Hee, MD, PhD*; Kim, June-Gone, MD, PhD*; Lee, Joo Yong, MD, PhD*

doi: 10.1097/IAE.0000000000002358
Original Study: PDF Only

Purpose: To compare the efficacy of intraoperative intravitreal dexamethasone implant for macular edema secondary to diabetic retinopathy (DME), retinal vein occlusion (RVO), and noninfectious posterior uveitis.

Methods: A retrospective review of 62 patients (29 men and 33 women; mean age 51.19 ± 14.41 years; 65 eyes) was performed. Best-corrected visual acuity (in logarithm of the minimal angle of resolution), central foveal thickness, intraocular pressure, and postoperative edema-free period were postoperatively assessed up to 1 year. The preoperative and postoperative numbers of other intravitreal injections needed were compared.

Results: Best-corrected visual acuity gradually improved in the DME group (from 0.87 to 0.51) but failed to improve from Month 3 onward in the RVO and uveitis groups. Central foveal thickness decreased in all groups, especially in the DME group (from 550.93 to 338.10 μm). Edema-free period was longest in the DME group (19.34 ± 15.12 months), followed by the uveitis (12.91 ± 7.85 months) and RVO (8.50 ± 8.76 months) groups. Subjects in the uveitis group used more intraocular pressure–lowering agents (1.00 ± 1.27) than those in the DME (0.13 ± 0.49) and RVO (0.36 ± 0.79) groups. Increased intraocular pressure events were most frequent in postoperative Week 1, especially in the uveitis group.

Conclusion: Vitrectomy combined with intravitreal dexamethasone implant for DME, RVO, and noninfectious posterior uveitis had a favorable clinical outcome.

Vitrectomy combined with intravitreal dexamethasone implant for macular edema secondary to diabetic retinopathy, retinal vein occlusion, and noninfectious posterior uveitis had a favorable clinical outcome.

*Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; and

Department of Ophthalmology, Quirino Memorial Medical Center, Quezon City, Manila, Philippines.

Reprint requests: Joo Yong Lee, MD, PhD, Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea; e-mail: ophthalmo@amc.seoul.kr

None of the authors has any financial/conflicting interests to disclose.

G. Son with whom coprimary authorship is shared.

© 2018 by Ophthalmic Communications Society, Inc.