To report the clinical course of eyes with paraneoplastic retinopathy caused by an autoantibody against transient receptor potential cation channel, subfamily M, member 1 (TRPM1).
Ten paraneoplastic retinopathy patients with retinal ON-bipolar cell dysfunction, including six melanoma-associated retinopathy, from eight institutions in Japan were evaluated for the presence of an anti-TRPM1 antibody. The results of ophthalmic examinations and the presence of anti-TRPM1 antibody were analyzed.
Five patients were positive for the anti-TRPM1 antibody. These patients had similar clinical findings in both eyes at the time of diagnosis; relatively preserved best-corrected visual acuity, absence of fundus and optical coherence tomography abnormalities, and specific abnormalities of the electroretinography (ERG); and negative-type ERGs with bright stimulus flashes. One patient whose retinal ON-bipolar cells remained dysfunctional for the entire testing period, although the anti-TRPM1 antibody had disappeared. On the other hand, the ERGs recovered in 2 cases within 2 years after the onset. One case progressed to additional impairment of the photoreceptors with deterioration of ERGs. One case died and the clinical course was unavailable.
Paraneoplastic retinopathy patients with retinal ON-bipolar cell dysfunction possess autoantibodies against TRPM1 at the onset of the disease process; however, the clinical course of these eyes can be different.
Patients with paraneoplastic retinopathy with ON-bipolar cell dysfunction occasionally have autoantibodies against TRPM1 at the onset of the disease process; however, the clinical course of these eyes can be different.
*Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan;
†Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan;
‡Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu City, Mie, Japan; and
§Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Reprint requests: Shinji Ueno, MD, PhD, Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan; e-mail: firstname.lastname@example.org
Grant-in-Aid for Scientific Research C (No. 16K11320 to SU) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (http://www.jsps.go.jp/).
None of the authors has any financial/conflicting interests to disclose.