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CHARACTERISTICS AND CLASSIFICATION OF TYPE 3 NEOVASCULARIZATION WITH B-SCAN FLOW OVERLAY AND EN FACE FLOW IMAGES OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Kataoka, Keiko, MD, PhD; Takeuchi, Jun, MD; Nakano, Yuyako, MD; Fujita, Ai, MD; Kaneko, Hiroki, MD, PhD; Ito, Yasuki, MD, PhD; Terasaki, Hiroko, MD, PhD

doi: 10.1097/IAE.0000000000002357
Original Study: PDF Only

Purpose: To study B-scan flow overlay and en face flow optical coherence tomography angiography (OCT-A) images of Type 3 neovascularization (NV) and to characterize a staging system for Type 3 NV based on the OCT-A findings.

Methods: We retrospectively collected data on consecutive treatment-naive eyes with Type 3 NV. All eyes underwent fluorescein angiography, indocyanine green angiography, structural spectral domain OCT, and OCT-A (AngioPlex). Localization and extension of abnormal flows detected by B-scan flow overlay and en face OCT-A images were assessed.

Results: Of 24 eyes of 22 patients with Type 3 NV, B-scan flow overlay images showed that 4.2% had telangiectatic flow in the deep retinal layer without outer plexiform layer disruption (Stage 1), 8.3% had downward intraretinal flow and subretinal flow without retinal pigment epithelium disruption (Stage 2), and 87.5% had downward flow and retinal pigment epithelium disruption (Stage 3). Of the Stage 3 eyes, 95.2% showed flow signal penetrating at the site of the retinal pigment epithelium disruption on the B-scan flow overlay images.

Conclusion: We showed the characteristics of Type 3 NV using B-scan flow overlay and en face OCT-A images. B-scan flow overlay OCT-A images seem useful to improve the detection and accurate diagnosis of Type 3 NV.

This retrospective case series assessed B-scan flow overlay and en face optical coherence tomography angiography images to reveal characteristics of neovascular flow of Type 3 neovascularization and propose a staging system based on the optical coherence tomography angiography findings.

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Reprint requests: Keiko Kataoka, MD, PhD, Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; e-mail: kkeiko@med.nagoya-u.ac.jp

Supported by the Japan Society for the Promotion of Science KAKENHI, Grant numbers 16K20313 (K.K.).

Presented in part at the 33rd Asia-Pacific Academy of Ophthalmology Congress, Hong Kong, China, February 8–11, 2018.

None of the authors has any financial/conflicting interests to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.retinajournal.com).

© 2018 by Ophthalmic Communications Society, Inc.