To study B-scan flow overlay and en face flow optical coherence tomography angiography (OCT-A) images of Type 3 neovascularization (NV) and to characterize a staging system for Type 3 NV based on the OCT-A findings.
We retrospectively collected data on consecutive treatment-naive eyes with Type 3 NV. All eyes underwent fluorescein angiography, indocyanine green angiography, structural spectral domain OCT, and OCT-A (AngioPlex). Localization and extension of abnormal flows detected by B-scan flow overlay and en face OCT-A images were assessed.
Of 24 eyes of 22 patients with Type 3 NV, B-scan flow overlay images showed that 4.2% had telangiectatic flow in the deep retinal layer without outer plexiform layer disruption (Stage 1), 8.3% had downward intraretinal flow and subretinal flow without retinal pigment epithelium disruption (Stage 2), and 87.5% had downward flow and retinal pigment epithelium disruption (Stage 3). Of the Stage 3 eyes, 95.2% showed flow signal penetrating at the site of the retinal pigment epithelium disruption on the B-scan flow overlay images.
We showed the characteristics of Type 3 NV using B-scan flow overlay and en face OCT-A images. B-scan flow overlay OCT-A images seem useful to improve the detection and accurate diagnosis of Type 3 NV.
This retrospective case series assessed B-scan flow overlay and en face optical coherence tomography angiography images to reveal characteristics of neovascular flow of Type 3 neovascularization and propose a staging system based on the optical coherence tomography angiography findings.
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Reprint requests: Keiko Kataoka, MD, PhD, Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; e-mail: firstname.lastname@example.org
Supported by the Japan Society for the Promotion of Science KAKENHI, Grant numbers 16K20313 (K.K.).
Presented in part at the 33rd Asia-Pacific Academy of Ophthalmology Congress, Hong Kong, China, February 8–11, 2018.
None of the authors has any financial/conflicting interests to disclose.
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