Secondary Logo

Share this article on:

CHANGES IN VISUAL ACUITY AND PHOTORECEPTOR DENSITY USING ADAPTIVE OPTICS AFTER RETINAL DETACHMENT REPAIR

Potic, Jelena, MD*,†; Bergin, Ciara, PhD*; Giacuzzo, Clarice, MD*; Daruich, Alejandra, MD*; Pournaras, Jean-Antoine, MD*; Kowalczuk, Laura, PhD*; Behar-Cohen, Francine, MD, PhD*,‡; Konstantinidis, Lazaros, MD*; Wolfensberger, Thomas J., MD*

doi: 10.1097/IAE.0000000000002378
Original Study: PDF Only

Purpose: To quantify changes in photoreceptor density using adaptive optics fundus camera in patients after retinal detachment (RD) and to correlate them with macular involvement and best-corrected visual acuity.

Methods: At 1 and 3 months (M1 and M3) after vitrectomy, 194 patients underwent adaptive optics imagery in both eyes, at 5 locations, that we matched between time points using anatomical landmarks. Twenty-two patients (10 fovea-OFF [OFF] and 12 fovea-ON [ON]) had matched and analyzable adaptive optics images. We used analysis of variance for repeated measures.

Results: Best-corrected visual acuity (logarithm of the minimum angle of resolution and Snellen equivalent [SE]) was significantly different between OFF and ON RDs at baseline: 2.0 (2.3–0.95) (SE: 20/2000) versus 0 (0.1–0) (SE: 20/20); at M1: 0.35 (0.5–0.1) (SE: 20/40) versus 0.05 (0–0.1) (SE: 20/25); and at M3: 0.25 (0.3–0.1) (SE: 20/32) versus 0 (0–0) (SE: 20/20). We observed that cone density was stable in fellow eyes between M1 and M3 (P = 0.67); decreased in treated eyes than in fellow eyes (P < 0.05); and increased postoperatively in the ON group (P = 0.02) but not in the OFF group (P = 0.97). Visual acuity and RD type were independently correlated with cone density (P = 0.004, P = 0.000).

Conclusion: Postoperative cone density was reduced in OFF RD, but also in the ON group, although the drop recovered during the 3-month follow-up. Cone density was significantly correlated with both visual acuity and type of RD at both time points.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

After successful pars plana vitrectomy for rhegmatogenous retinal detachment, in vivo cone density estimated with adaptive optics fundus camera postoperatively showed that cone density was significantly correlated with both visual acuity and type of retinal detachment.

*Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland;

Clinics for Eye Diseases, Clinical Center of Serbia, Department of Ophthalmology, School of Medicine, University of Belgrade, Belgrade, Serbia; and

Centre de Recherche des Cordeliers UMRS1138, INSERM, Paris, France.

Reprint requests: Thomas J. Wolfensberger, MD, Department of Ophthalmology, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Avenue de France 15, 1002 Lausanne, Vaud, Switzerland; e-mail: thomas.wolfensberger@fa2.ch

Presented at 16th Euretina Congress, Copenhagen, Denmark, September 9, 2016.

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.