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CHANGES IN CHOROIDAL THICKNESS IN CLINICALLY SIGNIFICANT PSEUDOPHAKIC CYSTOID MACULAR EDEMA

Fleissig, Efrat, MD*; Cohen, Shai, MD; Iglicki, Matias, MD; Goldstein, Michaella, MD*; Zur, Dinah, MD*

doi: 10.1097/IAE.0000000000001747
Original Study: PDF Only

Purpose: To investigate choroidal thickness in eyes with clinically significant pseudophakic cystoid macular edema (PCME) during the acute phase and following resolution of the edema, using enhanced depth imaging spectral domain optical coherence tomography (EDI-OCT).

Methods: This is a retrospective, observational clinical study. Patients' records were reviewed for cases of clinically significant PCME after uneventful phacoemulsification surgery. Choroidal thickness was measured at time of PCME diagnosis in both eyes and after CME resolution in the affected eye using enhanced depth imaging spectral domain optical coherence tomography (Spectralis; Heidelberg Engineering). Measurements were taken subfoveal and 1.5 mm nasal, temporal, inferior, and superior from the center of the fovea. Statistical analysis was performed using paired t-test and Pearson correlation.

Results: Mean subfoveal choroidal thickness in 34 eyes with PCME measured 258 ± 83 μm at baseline and decreased to 215 ± 79 μm after CME resolution (P < 0.001). Mean subfoveal choroidal thickness measured at baseline in fellow eyes was significantly lower (194 ± 77 μm) compared to acute PCME (P < 0.001) and after CME resolution (P = 0.011).

Conclusion: Choroidal thickness is increased in eyes with PCME and decreases following edema resolution. These findings may strengthen the hypothesis of an inflammatory pathogenesis in PCME.

Using enhanced-depth imaging optical coherence tomography, we found a significant increase of choroidal thickness in eyes with cystoid macular edema (CME) following uneventful phacoemulsification surgery and a decrease after edema resolution. The choroid in the affected eye was significantly thicker compared to the fellow eye at baseline and following CME resolution.

*Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; and

Department of Ophthalmology, Hospital de Clínicas José de San Martín, University of Buenos Aires, Buenos Aires, Argentina.

Reprint requests: Dinah Zur, MD, Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Weizman 6, Tel Aviv 64239, Israel; e-mail: dinahzur@gmail.com

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.