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A PROSPECTIVE, RANDOMIZED TRIAL COMPARING PLAIN GUT TO POLYGLACTIN 910 (VICRYL) SUTURES FOR SCLEROTOMY CLOSURE AFTER 23-GAUGE PARS PLANA VITRECTOMY

Sridhar, Jayanth, MD*,†; Kasi, Sundeep, MD*; Paul, Joshua, BS*; Shahlaee, Abtin, MD*; Rahimy, Ehsan, MD*; Chiang, Allen, MD*; Spirn, Marc, J., MD*; Hsu, Jason, MD*; Garg, Sunir, J., MD, FACS*

doi: 10.1097/IAE.0000000000001684
Original Study: PDF Only

Purpose: To report a prospective, randomized comparative study assessing clinical outcomes of plain gut versus polyglactin 910 (PG910) sutures for sclerotomy closure after 23-gauge pars plana vitrectomy.

Methods: A single-masked, randomized, prospective study was undertaken with 49 eyes of 49 patients undergoing 23-gauge pars plana vitrectomy randomized to sclerotomy closure with either plain gut suture, PG910 (Vicryl) suture or a combination of the two. Assessment was based on both a postoperative pain scale and a standardized assessment of scleral inflammation at each suture site.

Results: No wound leakage was noted postoperatively in any patient. Across all groups, scleral inflammation was significantly higher at the PG910 suture sites compared with the plain gut suture sites at both the 1-week (P = 0.04) and 1-month postoperative visits (P < 0.001). Patients with PG910 sutures reported greater pain at the 1-month postoperative visit than those with plain gut sutures (P = 0.018).

Conclusion: This prospective study suggests improved tolerability and reduced inflammation using plain gut suture compared with an 8-0 PG910 suture to close 23-gauge sclerotomies.

This single-masked, prospective study comparing pars plana vitrectomy sclerotomy closure with plain gut versus polyglactin 910 suture material found no complications with use of either suture. Scleral inflammation and pain were significantly less with use of plain gut suture.

*Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania; and

Bascom Palmer Eye Institute, University of Miami, Miami, Florida.

Reprint requests: Sunir J. Garg, MD, FACS, Mid-Atlantic Retina, The Retina Service of Wills Eye Hospital, 840 Walnut Street Suite 1020, Philadelphia, PA 19107; e-mail: sunirgarg@gmail.com

None of the authors has any financial/conflicting interests to disclose.

S. J. Garg had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

© 2018 by Ophthalmic Communications Society, Inc.