Institutional members access full text with Ovid®

Share this article on:

ASYMMETRIC DIABETIC RETINOPATHY PROGRESSION IN PATIENTS WITH AXIAL ANISOMETROPIA

Kim, Dong, Yoon, MD, PhD*; Song, Ji, Ho, MD*; Kim, Yoon, Jeon, MD, PhD; Lee, Joo, Yong, MD, PhD; Kim, June-Gone, MD, PhD; Yoon, Young, Hee, MD, PhD; Joe, Soo, Geun, MD, PhD

doi: 10.1097/IAE.0000000000002109
Original Study: PDF Only

Purpose: To investigate the differences in the progression of diabetic retinopathy (DR) in both eyes of patients with axial anisometropia.

Methods: A retrospective review was conducted on diabetic patients who had different axial lengths (difference greater than 1 mm) in each eye. The primary objective of this study was to analyze the differences in the progression of DR in both eyes of patients with axial anisometropia. Fundus images (fluorescein angiography and photographs of the fundus covering the Early Treatment Diabetic Retinopathy Study seven fields) were graded using the Early Treatment Diabetic Retinopathy Study DR grading system. Also, the severity of diabetic retinopathy was analyzed based on the axial length and subfoveal choroidal thickness.

Results: Thirty-four of 6,963 patients with DR were included after applying the exclusion and inclusion criteria. The mean age was 53.53 ± 12.20 years and duration of diabetes was 9.63 ± 7.73 years. The mean axial length of the longer and shorter eye was 26.21 ± 2.04 mm and 23.21 ± 1.73 mm, respectively (P < 0.001). In shorter eyes, 61.7% (21 of 34) of the eyes had proliferative diabetic retinopathy. In contrast to the shorter eye, only 8 of the longer eyes (8 of 34, 23.5%) had proliferative diabetic retinopathy (McNemar test, P < 0.001). In eyes with thin subfoveal choroidal thickness (<250 µm), the proliferative diabetic retinopathy ratio was significantly lower (P = 0.007).

Conclusion: In patients with axial anisometropia, the longer eye had a lower degree of DR progression than the shorter eye. This result showed that elongation of the axial length had a protective effect against the progression of DR without individual confounding factors.

In patients with axial anisometropia, longer eye had a lower degree of diabetic retinopathy progression than shorter eye. This showed that axial length elongation had a protective effect against progression of diabetic retinopathy without individual confounding factors.

*Department of Ophthalmology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea;

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and

Department of Ophthalmology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.

Reprint requests: Soo Geun Joe, MD, PhD, Department of Ophthalmology, Gangneung Asan Hospital, University of Ulsan College of Medicine, 38, Bangdong-gil, Sacheon-myeon, Gangneung-si, Gangwon-do, 25440, Korea; e-mail: jsg1105@gmail.com

Presented at American Society of Retina Specialists (ASRS) 2015 Annual Meeting, July, Wien, Austria.

None of the authors has any financial/conflicting interests to disclose.

Design of the study: D.Y.K., Y.J.K., and S.G.J.; collection and management of the data: D.Y.K., J.H.S., Y.J.K., and S.G.J.; analysis and interpretation of the data: D.Y.K., Y.J.K., and S.G.J.; preparation of the manuscript, and statistical analysis and interpretation: D.Y.K., S.G.J., Y.J.K., J.-G.K., Y.H.Y., J.Y.L., and S.G.J.; review and approval of the manuscript: D.Y.K., S.G.J, Y.J.K., J.-G.K., Y.H.Y., J.Y.L., and S.G.J.

© 2018 by Ophthalmic Communications Society, Inc.