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ASSOCIATIONS BETWEEN INDIVIDUAL RETINAL LAYER THICKNESSES AND DIABETIC PERIPHERAL NEUROPATHY USING RETINAL LAYER SEGMENTATION ANALYSIS

Kim, Jin Hyung, MD*; Lee, Min Woo, MD; Byeon, Suk Ho, MD; Kim, Sung Soo, MD*; Koh, Hyoung Jun, MD*; Lee, Sung Chul, MD*; Kim, Min, MD

doi: 10.1097/IAE.0000000000001835
Original Study: PDF Only

Purpose: To evaluate clinical correlations between the thicknesses of individual retinal layers in the foveal area of diabetic patients and the presence of diabetic peripheral neuropathy (DPN).

Methods: This retrospective, observational, cross-sectional study enrolled a total of 120 eyes from 120 patients. The eyes were divided into 3 groups: normal controls (n = 42 eyes), patients with diabetes mellitus (n = 42 eyes) but no DPN, and patients with diabetes mellitus and DPN (n = 36 eyes). The primary outcome measures were the thickness of all retinal layers in the central 1-mm zone measured using the segmentation analysis of spectral-domain optical coherence tomography. Correlations between the thicknesses of the individual retinal layers and the presence of DPN were also analyzed. Logistic regression analyses were used to determine which change in layer thickness had the most significant association with the presence of DPN.

Results: The mean thicknesses and the ratios of retinal nerve fiber layers to total retina thicknesses in the DPN group were 10.77 ± 1.79 μm and 4.10 ± 0.55%, which was significantly lower than those in normal controls and the diabetes mellitus with no DPN group (P = 0.014 and P = 0.001, respectively). Logistic regression analyses also showed that the decrease in thicknesses of the retinal nerve fiber layers and the inner nuclear layer are significant factors for predicting a higher risk for DPN development (odds ratio = 7.407 and 1.757; P < 0.001 and P = 0.001, respectively).

Conclusion: A decrease in the retinal nerve fiber layer and the inner nuclear layer thickness was significantly associated with the presence of DPN.

The thinning of retinal nerve fiber layer in macula of diabetic patients was found to have significant association with the development of diabetic peripheral neuropathy using retinal layer segmentation analysis of spectral-domain optical coherence tomography.

*Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; and

Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Reprint requests: Min Kim, MD, Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonjuro, Gangnam-gu, Seoul 135-270, Korea; e-mail: minkim76@gmail.com

Supported by a faculty research grant of the Yonsei University College of Medicine for 2012 (3-2012-0137) and the Student's Association of the Graduate School of the Yonsei University funded by the Graduate School of the Yonsei University.

None of the authors has any conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.