To define injection index (ii) and assess its impact on visual acuity (VA) in pigment epithelial detachment from age-related macular degeneration over 5 years.
Injection index is defined as the mean anti-vascular endothelial growth factor (anti-VEGF) injections per year from presentation. A retrospective study of 256 eyes in 213 patients was performed. Patients were stratified by ii (high: ≥9, low: <9).
Baseline characteristics showed no differences across ii groups. Mean (range) follow-up, in years, was 5.02 (1.04-12.74) for all patients. Mean logMAR VA [Snellen VA] were 0.60 [20/80] and 0.56 [20/73] at baseline, 0.52 [20/66] and 0.59 [20/78] at year 1, 0.45 [20/56] and 0.67 [20/94] at year 2, 0.38 [20/48] and 0.66 [20/91] at year 3, 0.41 [20/51] and 0.89 [20/155] at year 4, and 0.35 [20/45] and 0.79 [20/123] at year 5 for the high and low ii groups, respectively. Linear regression analysis showed a gain of 0.5 approxETDRS letters with each additional injection per year.
Increased ii was associated with better mean VA, suggesting long-term continuous VEGF suppression may improve VA in eyes thought to carry poor prognoses.