Original StudyCLINICAL PREDICTORS OF TUBERCULAR RETINAL VASCULITIS IN A HIGH-ENDEMIC COUNTRYKaza, Hrishikesh DNB*; Tyagi, Mudit MS*; Pathengay, Avinash FRCS†; Basu, Soumyava MS‡Author Information *L V Prasad Eye Institute, KAR Campus, Hyderabad, India; †L V Prasad Eye Institute, GMRV Campus, Visakhapatnam, India; and ‡L V Prasad Eye Institute, MTC Campus, Bhubaneswar, India. Reprint requests: Soumyava Basu, MS, L V Prasad Eye Institute, MTC Campus, Bhubaneswar, Odisha, India 751024; e-mail: [email protected] None of the authors has any financial/conflicting interests to disclose. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.retinajournal.com). Retina: February 2021 - Volume 41 - Issue 2 - p 438-444 doi: 10.1097/IAE.0000000000002829 Buy SDC Metrics AbstractIn Brief Purpose: To determine clinical signs suggestive of tubercular etiology in retinal vasculitis. Methods: A retrospective comparative study of patients who presented with retinal vasculitis at three tertiary care centers in India. All patients underwent detailed clinical evaluation and tailored laboratory investigations for etiological diagnosis. Tubercular etiology was diagnosed on basis on the presence of retinal periphlebitis in association with ancillary evidence of systemic tuberculosis and exclusion of nontuberculosis entities. Patients with tubercular (Group A) and nontubercular (Group B) etiology were compared for demographic characteristics, supportive diagnostic evidence, and specific ocular signs. Statistical analysis was performed at 5% confidence levels. Results: Of the 114 patients diagnosed with retinal vasculitis, Group A had 69 patients (100 eyes) and Group B had 45 patients (75 eyes). Active or healed subvascular lesions (P ≤ 0.0001), focal vascular tortuosity (P ≤ 0.0001), and occlusive vasculitis (P = 0.002) were significantly more common in Group A patients than in Group B patients. All three were independent predictors of tubercular etiology on multivariate regression analysis. Conclusion: The presence of healed or active subvascular lesions, focal vascular tortuosity, and occlusive vasculitis could be predictive of tubercular etiology in retinal vasculitis. A retrospective comparative study between clinically diagnosed tubercular and nontubercular retinal vasculitis revealed three clinical signs that could predict the tubercular origin of retinal vasculitis. These were healed or active subvascular lesions, focal vascular tortuosities, and occlusive vasculitis.