To combine advances in high-speed, wide-field optical coherence tomography angiography (OCTA
) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion
in patients with diabetic retinopathy
Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA
imaging using 12 mm × 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to quantify areas of capillary nonperfusion
The mean percentage of nonperfused area was 0.1% (95% confidence interval: 0.0–0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2–3.7) in the nonproliferative DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval: 5.0–14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to eyes with proliferative DR.
Conclusion: Capillary nonperfusion
area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA
. Quantitative analysis of retinal nonperfusion on wide-field OCTA
may be useful for early detection and monitoring of disease in patients with diabetes and DR.