We aimed to describe the clinical and histologic findings in a few enucleation
cases with intraocular lymphoma
Retrospective review of pathology files from a 22-year period identified cases with intraocular lymphoma
among all enucleation
specimens. Patient demographics, clinical findings, laboratory results, radiographic studies, and indication for enucleation
were abstracted from electronic health records; slides were reviewed.
Four patients (three women and one man; age range, sixth through eighth decades of life) underwent enucleation
with a final diagnosis of intraocular lymphoma
. Two patients with primary vitreoretinal large B-cell lymphomas had been treated for refractory uveitis. Specimens showed retinal and subretinal infiltrates by atypical large B-lymphocytes and rare neoplastic cells in the vitreous. The remaining two patients had systemic lymphoproliferative disorders. One patient had chronic lymphocytic leukemia and floaters in his eye
; vitreoretinal lymphoma
developed, consistent with intraocular Richter transformation. The other had diffuse large B-cell lymphoma
in remission; however, blurred vision developed, she was treated for panuveitis without improvement, and was later found to have ocular involvement by diffuse large B-cell lymphoma
Our series details the unusual circumstances when an eye
is removed for intraocular lymphoma
. Different patterns of ocular tissue involvement were observed when we compared primary and secondary lymphomas.