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OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN ADULT-ONSET FOVEOMACULAR VITELLIFORM DYSTROPHY

Joshi, Komal, M., MD; Nesper, Peter, L., BA; Fawzi, Amani, A., MD; Mirza, Rukhsana, G., MD

doi: 10.1097/IAE.0000000000001565
Original Study

Purpose: To determine the ability of optical coherence tomography angiography (OCTA) to detect choroidal neovascularization (CNV) in the pseudohypopyon stage of adult-onset foveomacular vitelliform dystrophy.

Methods: Prospective case series of eight consecutive patients with adult-onset foveomacular vitelliform dystrophy with at least one eye in the pseudohypopyon stage (a total of 14 eyes). Patients were assessed with spectral domain OCT, flourescein angiography, and OCTA. Main outcome measures were the presence or absence of CNV and any unifying patterns that could be identified on OCTA for adult-onset foveomacular vitelliform dystrophy.

Results: One (12.5%) of eight eyes in the pseudohypopyon stage had CNV on OCTA, without definitive evidence of CNV on flourescein angiography. Twelve of 14 eyes (86%) had OCTA segmentation errors, giving the false appearance of deep capillary plexus drop out. All 14 eyes (100%) had blockage of flow signal under the vitelliform lesion on OCTA that presented as artifactual loss of flow in the choriocapillaris.

Conclusion: Optical coherence tomography angiography may be superior to flourescein angiography in detecting CNV in adult-onset foveomacular vitelliform dystrophy, especially in the pseudohypopyon stage. There are common artifacts that must be considered when analyzing vitelliform lesions with OCTA, including segmentation errors and inability to visualize flow under the vitelliform lesion in the choriocapillaris.

This study analyzed eyes in the pseudohypopyon stage of adult-onset foveomacular vitelliform dystrophy on optical coherence tomography angiography to determine the ability of optical coherence tomography angiography to detect choroidal neovascularization and found that optical coherence tomography angiography may be superior to fluorescein angiography in detecting choroidal neovascularization in these patients.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Reprint requests: Rukhsana G. Mirza, MD, Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 North Michigan Avenue, Suite 440, Chicago, IL 60611; e-mail: r-mirza@northwestern.edu

Supported in part by an unrestricted grant from Research to Prevent Blindness.

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.