Original StudyCHOROIDAL BLOOD FLOW AND THICKNESS AS PREDICTORS FOR RESPONSE TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY IN MACULAR EDEMA SECONDARY TO BRANCH RETINAL VEIN OCCLUSIONOkamoto, Masahiro MD, PhD*; Yamashita, Mariko MD*; Sakamoto, Taiji MD, PhD†; Ogata, Nahoko MD, PhD*Author Information *Department of Ophthalmology, Nara Medical University, Kashihara, Japan; and †Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Reprint requests: Masahiro Okamoto, MD, PhD, Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan; e-mail: [email protected] None of the authors has any financial/conflicting interests to disclose. M. Okamoto: design of the study; M. Okamoto and N. Ogata: conduct of the study; M. Okamoto and M. Yamashita: collection of the data; M. Okamoto and M. Yamashita: management of the data; M. Okamoto and M. Yamashita: analysis of the data; M. Okamoto and N. Ogata: interpretation of the data; M. Okamoto: preparation of the manuscript; N. Ogata: review and approval of the manuscript. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.retinajournal.com). Retina: March 2018 - Volume 38 - Issue 3 - p 550-558 doi: 10.1097/IAE.0000000000001566 Buy SDC Metrics AbstractIn Brief Purpose: To determine the choroidal blood flow and subfoveal choroidal thickness (SCT) in eyes with macular edema secondary to branch retinal vein occlusion (BRVO). Methods: Thirty-two eyes of 32 patients with macular edema secondary to a BRVO were treated with a single intravitreal injection of ranibizumab (IVR) and were followed for 2 months. The central retinal thickness and SCT, and the retinal and choroidal blood flows were evaluated, and they were compared between the recurrent and resolved groups. Results: At the baseline, the SCT of eyes with a BRVO was significantly thicker than that of the fellow eye (P < 0.01). It was also significantly thicker in the recurrent group than in the resolved group (P = 0.03). The reduction of the retinal blood flow was found only after 1 week in the resolved group. The SCT and choroidal blood flow were significantly reduced during the follow-up period in the resolved group but not in the recurrent group. Conclusion: The choroid is involved in the pathology of BRVO and the SCT at the baseline may be a predictive factor in the treatment of intravitreal injection of ranibizumab for macular edema secondary to BRVO. The authors found that an intravitreal injection of ranibizumab affected the choroidal blood flow and choroidal thickness in eyes with branch retinal vein occlusion. More importantly, the results suggest that branch retinal vein occlusion is not entirely a retinal disorder and that choroidal finding can be a good predictor of effectiveness of the treatment.