Secondary Logo

Institutional members access full text with Ovid®

Share this article on:

EVALUATION OF MACULAR ISCHEMIA IN EYES WITH BRANCH RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study

Kadomoto, Shin, MD*,†; Muraoka, Yuki, MD, PhD*; Ooto, Sotaro, MD, PhD*; Miwa, Yuko, MD*; Iida, Yuto, MD*; Suzuma, Kiyoshi, MD, PhD*; Murakami, Tomoaki, MD, PhD*; Ghashut, Rima, MD*; Tsujikawa, Akitaka, MD, PhD; Yoshimura, Nagahisa, MD, PhD*,†

doi: 10.1097/IAE.0000000000001541
Original Study

Purpose: To quantitatively assess macular morphology and perfusion status using optical coherence tomography, and optical coherence tomography angiography in eyes with branch retinal vein occlusion when macular edema has completely resolved, and to investigate the impact on visual function.

Methods: Thirty consecutive eyes with branch retinal vein occlusion–macular edema that resolved after treatment with intravitreal ranibizumab injections were included. Macular sensitivity was measured by microperimetry; defect length of foveal ellipsoid zone band was measured using optical coherence tomography; foveal avascular zone and parafoveal nonperfusion areas (NPA) were measured by optical coherence tomography angiography.

Results: The logarithm of minimum angle of resolution visual acuity was significantly associated with the defect length of the foveal ellipsoid zone band (P = 0.005), the parafoveal NPA in the superficial capillary plexus (P = 0.007), and the parafoveal NPA in the deep capillary plexus (P = 0.006). Macular sensitivity correlated with parafoveal thickness on the affected side (P = 0.034), the defect length of the foveal ellipsoid zone band (P = 0.048), parafoveal NPA in the superficial capillary plexus (P = 0.008), and parafoveal NPA in the deep capillary plexus (P = 0.012). Multivariate analysis where the only significant parameters in the univariate analyses were used as the independent variables showed that parafoveal NPA was most significantly associated with the logarithm of minimum angle of resolution visual acuity (β = 0.500, P = 0.005) and macular sensitivity (β = −0.480, P = 0.007).

Conclusion: In eyes with branch retinal vein occlusion–macular edema resolved by intravitreal ranibizumab treatments, visual function was strongly associated with parafoveal NPA size.

In eyes with branch retinal vein occlusion, visual function was most strongly associated with the size of the parafoveal nonperfusion area when macular edema and hemorrhage were resolved by anti–vascular endothelial growth factor treatment.

*Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan;

Department of Ophthalmology, Kitano Hospital, Osaka, Japan; and

Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.

Reprint requests: Yuki Muraoka, MD, PhD, Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan; e-mail: muraoka@kuhp.kyoto-u.ac.jp

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.retinajournal.com).

© 2018 by Ophthalmic Communications Society, Inc.