To determine the incidence and clinical characteristics of angiographic subtypes of polypoidal choroidal vasculopathy
It is a prospective, multicenter, cross-sectional study. Patients with newly diagnosed exudative macular degeneration are classified into PCV, age-related macular degeneration
(AMD), and retinal angiomatous proliferation
. Polypoidal choroidal vasculopathy
is further classified into two subtypes depending on the presence (Type 1: polypoidal choroidal neovascularization
) or absence (Type 2: typical PCV) of feeder vessels on indocyanine green angiography.
We enrolled 169 patients: 76 (45%) with PCV, 75 (44.4%) with AMD, and 14 (8.3%) with retinal angiomatous proliferation
. Of the patients with PCV, 20 (26%) were classified as Type 1 PCV and 56 (74%) were classified as Type 2 PCV. The Type 1 PCV had a similar mean age compared to the AMD group (73.1 ± 9.6 vs. 75.6 ± 8.8 years, P
= 0.281) and the Type 2 PCV (68.8 ± 9.6 years) was younger than the AMD group (P
< 0.001). Type 1 PCV presented with worse visual acuity compared with the AMD. Both PCV subtypes had a higher incidence of hemorrhagic complications (85% and 75% respectively).
Type 2 PCV is more common than Type 1 PCV in Taiwan. Our results support the hypothesis that polypoidal choroidal neovascularization
and typical PCV may be distinct entities.