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Yeung, Ling, MD*,†; Kuo, Chien-Neng, MD†,‡; Chao, An-Ning, MD†,§; Chen, Kuan-Jen, MD†,§; Wu, Wei-Chi, MD, PhD†,§; Lai, Chien-Hsiung, MD†,‡; Wang, Nan-Kai, MD†,§; Hwang, Yih-Shiou, MD†,§; Chen, Ching-Lung, MD†,‡; Lai, Chi-Chun, MD†,‡

doi: 10.1097/IAE.0000000000001556
Original Study

Purpose: To determine the incidence and clinical characteristics of angiographic subtypes of polypoidal choroidal vasculopathy (PCV).

Methods: It is a prospective, multicenter, cross-sectional study. Patients with newly diagnosed exudative macular degeneration are classified into PCV, age-related macular degeneration (AMD), and retinal angiomatous proliferation. Polypoidal choroidal vasculopathy is further classified into two subtypes depending on the presence (Type 1: polypoidal choroidal neovascularization) or absence (Type 2: typical PCV) of feeder vessels on indocyanine green angiography.

Results: We enrolled 169 patients: 76 (45%) with PCV, 75 (44.4%) with AMD, and 14 (8.3%) with retinal angiomatous proliferation. Of the patients with PCV, 20 (26%) were classified as Type 1 PCV and 56 (74%) were classified as Type 2 PCV. The Type 1 PCV had a similar mean age compared to the AMD group (73.1 ± 9.6 vs. 75.6 ± 8.8 years, P = 0.281) and the Type 2 PCV (68.8 ± 9.6 years) was younger than the AMD group (P < 0.001). Type 1 PCV presented with worse visual acuity compared with the AMD. Both PCV subtypes had a higher incidence of hemorrhagic complications (85% and 75% respectively).

Conclusion: Type 2 PCV is more common than Type 1 PCV in Taiwan. Our results support the hypothesis that polypoidal choroidal neovascularization and typical PCV may be distinct entities.

Among two angiography subtypes of polypoidal choroidal vasculopathy (PCV), Type 2 PCV (typical PCV) is more common than Type 1 PCV (polypoidal choroidal neovascularization) in Taiwan. Only Type 1 PCV subgroup has similar demographics with age-related macular degeneration (AMD). Both subgroups have a high incidence of hemorrhage complications when compared with AMD.

*Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan;

College of Medicine, Chang Gung University, Taoyuan, Taiwan;

Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi, Taiwan; and

§Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Reprint requests: Chi-Chun Lai, MD, Department of Ophthalmology, Chang Gung Memorial Hospital, No. 5, Fu-Shin Street, Kweishan, Taoyuan 333, Taiwan; e-mail:

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.