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INVOLVEMENT OF MULTIPLE MOLECULAR PATHWAYS IN THE GENETICS OF OCULAR REFRACTION AND MYOPIA

Wojciechowski, Robert, OD, PhD*,†,‡; Cheng, Ching-Yu, MD, PhD§,¶,**

doi: 10.1097/IAE.0000000000001518
Original Study

Purpose: The prevalence of myopia has increased dramatically worldwide within the last three decades. Recent studies have shown that refractive development is influenced by environmental, behavioral, and inherited factors. This review aims to analyze recent progress in the genetics of refractive error and myopia.

Methods: A comprehensive literature search of PubMed and OMIM was conducted to identify relevant articles in the genetics of refractive error.

Results: Genome-wide association and sequencing studies have increased our understanding of the genetics involved in refractive error. These studies have identified interesting candidate genes. All genetic loci discovered to date indicate that refractive development is a heterogeneous process mediated by a number of overlapping biological processes. The exact mechanisms by which these biological networks regulate eye growth are poorly understood. Although several individual genes and/or molecular pathways have been investigated in animal models, a systematic network-based approach in modeling human refractive development is necessary to understand the complex interplay between genes and environment in refractive error.

Conclusion: New biomedical technologies and better-designed studies will continue to refine our understanding of the genetics and molecular pathways of refractive error, and may lead to preventative and therapeutic measures to combat the myopia epidemic.

Here, the authors review the results of recent epidemiological and genome-wide association studies into the molecular pathways and genetics underlying ocular refraction and myopia, the prevalence of which is reaching epidemic proportions in East Asia. The authors examine the complex mixture of factors contributing to myopia and discuss strategies for future research.

*Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland;

Computation Genomics Branch, National Human Genome Research Institute, Baltimore, Maryland;

§Singapore Eye Research Institute, Singapore National Eye Centre, Singapore;

Duke-NUS Medical School, Singapore; and

**Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Reprint requests: Ching-Yu Cheng, MD, PhD, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; e-mail: chingyu.cheng@duke-nus.edu.sg

C.-Y. Cheng is supported by an award from the National Medical Research Council, Singapore (CSA/033/2012). R. Wojciechowski is supported by a Clinical Investigator Award (1K08EY022943), from the US National Eye Institute (NIH).

C.-Y. Cheng has received support for travel to the Second International Conference of Pathologic Myopia, Kyoto, Japan, from Novartis Pharma K. K., Japan. R. Wojciechowski has no financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.