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A Systematic Review and Meta-Analysis

Feng, XiaoXiao MD*; Li, Cheng MD*; Zheng, Qishan MD*; Qian, XiaoBin g*; Shao, WanWen*; Li, YuJie*; Li, Wei PhD; Yin, Lu PhD; Wang, Yang PhD; Gao, QianYing MD, PhD*

doi: 10.1097/IAE.0000000000001553

Purpose: The authors examined the differences between silicone oil and other vitreous tamponades or placebo in performing pars plana vitrectomy.

Methods: This review and meta-analysis was conducted in accordance with the PRISMA guidelines. Seven databases and the reference lists of the retrieved randomized controlled trial articles were searched to identify eligible studies. The primary outcomes were the rate of redetachment after endotamponade removal, the rate of reoperation, and poor visual acuity. The secondary outcomes were adverse events and quality of life related to postoperative position.

Results: Ten articles (12 trials) were included. There were no significant differences between silicone oil and other agents in most of the primary and second outcomes. Only the risk of hypotony was found to be significantly lower when filling with silicone oil, compared with other agents. No trial reported the quality of life related to postoperative position.

Conclusion: Based on the available studies, the authors conclude that there is no significant difference in the risk of poor outcomes between pars plana vitrectomy with silicone oil and that with other vitreous tamponades with different surgical histories.

In this meta-analysis, the authors compared the safety of silicone oil as a vitreous tamponade in pars plana vitrectomy with that of placebo and other tamponade agents. The authors found no significant differences in the risk of poor outcomes, suggesting that silicone oil may be an appropriate choice of tamponade.

*Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China; and

Director of Statistics Medical Research & Biometrics Center, National Center for Cardiovascular Disease, Fuwai Hospital, Beijing, China.

Reprint requests: Qianying Gao, MD, PhD, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; e-mail:

Supported by the National Natural Science Foundation of China (81271008), Science and Technology Planning Project of Guangdong Province, China (2015B020211004).

None of the authors has any conflicting interests to disclose.

All aspects of the meta-analysis were performed under the auspices of writers. X. Feng, C. Li, Q. Zheng, X. Qian, L. Yin, Y. Wang collated data, contributed to the discussions of the results, analyzing data, and commented on drafts of the report. The project was organized by W. Shao and Y. Li, who were responsible for formulating the question, developing the protocol, receiving, and checking data. The project was managed by Q. Gao and W. Li. The report was drafted by X. Feng.

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© 2017 by Ophthalmic Communications Society, Inc.