To describe anatomical relationships of retinal neovascular complexes (NVCs) and the posterior vitreous
in proliferative diabetic retinopathy
using spectral domain optical coherence tomography
Cross-sectional study. Neovascular complexes were imaged using spectral domain optical coherence tomography
in 51 eyes of 37 patients. The relationship of NVCs to the posterior vitreous cortex
and posterior vitreous
spaces, such as the premacular bursa
, prevascular vitreous
fissures, and perimacular cisterns, was analyzed.
In the 77 NVCs evaluated, 61 (79%) had grown along the outer surface of the posterior hyaloid face, and vitreoschisis
was present in 37 (48%). The “wolf's jaw” configuration was present in 9% and resulted from NVC arising from the arcades and proliferating along the posterior hyaloid face. By contrast, NVCs that invaded the bursa originated from smaller venous tributaries more distant from the arcades. The premacular bursa
and prevascular vitreous fissure
/perimacular cistern were invaded infrequently, respectively, in 15% and 38% (P
Tomographic analysis of diabetic NVCs showed that most NVCs arise and grow along the posterior hyaloid face and that vitreoschisis
is more prevalent than what has been found in ultrasound studies. The wolf's jaw configuration does not seem to result from the invasion of the bursa, as previously suggested.