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INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS

Clinical Findings and Time-Related Changes

Maertz, Josef MD*; Mohler, Kathrin J. M.Sc; Kolb, Jan P. Dipl Phys†,‡; Kein, Thomas PhD; Neubauer, Aljoscha MD*; Kampik, Anselm MD*; Priglinger, Siegfried MD*; Wieser, Wolfgang PhD; Huber, Robert PhD†,‡; Wolf, Armin MD*

doi: 10.1097/IAE.0000000000001260
Original Study
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Purpose: To investigate the structural changes of intrapapillary proliferations associated with optic disk pits (ODPs) and optic disk pit maculopathy (ODP-M) using enhanced depth-spectral domain-optical coherence tomography (SD-EDI-OCT) and megahertz optical coherence tomography (MHz-OCT).

Methods: Sixteen eyes of patients with ODPs were studied. Papillary and peripapillary areas were repeatedly examined with SD-EDI-OCT over time. To evaluate swept-source OCT, some of the patients additionally received MHz-OCT-imaging.

Results: MHz-OCT or SD-EDI images showed the entire form of the pits from opening to bottom in 13 of the 16 cases. The shape of ODPs varied considerably. In patients with unilateral ODP, deep intrapapillary depressions in the optic disk of the contralateral partner eye were a prevalent finding. Intrapapillary proliferations were observed in all ODP-cases during follow-up. The aspect of intrapapillary and prepapillary tissue, septae, and cavities changed over time. This effect was especially pronounced inside the ODP while the eye experienced simultaneous ODP-M.

Conclusion: All examined eyes with ODP showed signs of intrapapillary and prepapillary tissue, which developed over time. SD-EDI-OCT and MHz-OCT are able to detect characteristic ODP-related findings and are a useful means to monitor time-related changes within intrapapillary and prepapillary tissue related to ODP and ODP-M.

Eyes with optic disk pit (ODP) show signs of intrapapillary proliferation. SD-EDI-OCT and MHz-OCT are able to detect characteristic ODP-related findings such as retinoschisis, subretinal fluid, vitreous fibers, or lamina cribrosa defects, and are a useful means to monitor time-related changes within intrapapillary proliferations related to ODP and ODP-maculopathy.

*Department of Ophthalmology, Ludwig-Maximilians University Munich, Munich, Germany;

Institute for Biomolecular Optics, Faculty of Physics, Ludwig-Maximilians-University, Munich, Germany; and

Institute of Biomedical Optics, University of Lübeck, Germany.

Reprint requests: Armin Wolf, MD, Dr. Med, Department of Ophthalmology, Ludwig-Maximilians-University, Klinikum der Universität München, Campus Innenstadt, Mathildenstrasse 8, D-80336 Munich, Germany; e-mail: armin.wolf@med.uni-muenchen.de

K. J. Mohler, J. P. Kolb, T. Klein, W. Wieser, and R. Huber: this research was sponsored by the Gesellschaft der Freunde und Förderer der Augenklinik der LMU München e. V., by the German Research Foundation (DFG) (project HU1006/6–1) and by the European Union project FDML-Raman (FP7 ERC, contract no. 259158). T. Klein, W. Wieser, and R. Huber: disclose financial interest in Optores GmbH.

A. Wolf: this research was partly supported by a Novartis research grant.

T. Klein, W. Wieser, and R. Huber: disclose financial interest in Optores GmbH. The other authors have no financial/conflicting interests to disclose.

© 2017 by Ophthalmic Communications Society, Inc.