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Pak, Kang Yeun MD; Park, Sung Who MD; Byon, Ik Soo MD; Lee, Ji Eun MD, PhD

doi: 10.1097/IAE.0000000000001195
Original Study

Purpose: To investigate the efficacy of a treat-and-extend regimen (TER) using ranibizumab to treat polypoidal choroidal vasculopathy (PCV).

Methods: We retrospectively reviewed the medical records of 29 patients with PCV, who had been treated with a TER for 1 year. The primary outcome was the proportion of eyes that did not lose ≥3 best-corrected visual acuity (BCVA) lines. The number of intravitreal injections and recurrences as well as the maximum treatment interval without recurrence were analyzed.

Results: The mean BCVA improved from 0.64 ± 0.42 logMAR (median, 20/80) at baseline to 0.30 ± 0.31 logMAR (median, 20/30) at 12 months (P < 0.001). The mean central subfield macular thickness improved from 307.0 ± 70.2 μm to 237.5 ± 64.4 μm (P < 0.001). None of the subjects lost ≥3 lines, and 15 (51.7%) gained ≥3 lines. The mean number of injections was 7.0. The mean maximum treatment interval without recurrence was 10.0 weeks. After the loading phase, 12 eyes (41.4%) showed no recurrence. Seven eyes (24.1%) demonstrated disease activity at 12 months, and 4 (13.8%) of them were never dry during the entire 12-month follow-up duration.

Conclusion: The TER effectively improved visual acuity in PCV while reducing the number of injections.

A treat-and-extend regimen using ranibizumab improved visual acuity in patients with polypoidal choroidal vasculopathy who responded to ranibizumab injections for 1 year. The number of intravitreal injections as well as the number of visits could be reduced without loss of visual acuity.

*Department of Ophthalmology, School of Medicine, Pusan National University, Yangsan, South Korea;

Medical Research Institute, Pusan National University Hospital, Busan, South Korea; and

Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.

Reprint requests: Ji Eun Lee, MD, PhD, Pusan National University Hospital, Ami dong 1-10, Seo-gu, Busan, 49241 South Korea; e-mail:

J. E. Lee: Research fund from Bayer, and Consultation and honorarium from Novartis, Bayer, and Allergan. The other authors have no financial/conflicting interests to disclose.

© 2017 by Ophthalmic Communications Society, Inc.