Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

RETINAL PIGMENT EPITHELIUM APERTURE: A Previously Unreported Finding in the Evolution of Avascular Pigment Epithelium Detachment

Querques, Giuseppe MD, PhD; Capuano, Vittorio MD; Costanzo, Eliana MD; Corvi, Federico MD; Querques, Lea MD; Introini, Ugo MD; Souied, Eric H. MD, PhD; Bandello, Francesco MD, FEBO

doi: 10.1097/IAE.0000000000001231
Original Study

Purpose: To describe retinal pigment epithelium (RPE) aperture and to generate hypotheses about pathogenesis of this previously unreported finding in the evolution of avascular pigment epithelium detachment (PED) secondary to age-related macular degeneration.

Methods: Medical records and multimodal imaging results from 10 patients with RPE apertures were reviewed between January 2009 and December 2014 by 2 institutions. Main outcome measures were analysis of RPE aperture imaging characteristics, including aperture areas and PED diameters, and their temporal course. Lesions preceding RPE aperture development were also evaluated.

Results: Eleven RPE apertures were identified in 10 eyes of 10 patients (1 male, 9 females; mean age 73.1 ± 6.7 years) and included for analysis. The RPE apertures appeared as round discontinuities either at the apex or at the base of avascular PED. No rippling or retraction of the RPE was found at the sites of aperture. The RPE apertures enlarged homogeneously (mean round area of hypoautofluorescence significantly increased from 0.18 ± 0.13 to 0.93 ± 1.2; P = 0.005), and PED flattened (PED maximal height on spectral domain optical coherence significantly decreased from 445.2 ± 259 to 206.4 ± 218; P = 0.04) after a mean of 38.6 ± 16.3 months. Analysis of lesions preceding RPE apertures revealed areas of focal hyperautofluorescence at the site of development, in some cases appearing as drusenoid material connected with the base of avascular PED.

Conclusion: The RPE aperture represents a previously unreported possible evolution of avascular PED, which should be distinguished by typical RPE tears. Analysis of lesions preceding RPE apertures suggests focal atrophic progression of drusenoid material in its pathogenesis.

In this study, we describe the presence of retinal pigment epithelium aperture, which represents a previously unreported possible evolution of avascular pigment epithelium detachment and investigated a possible causal association.

*Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy; and

Department of Ophthalmology, Hopital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France.

Reprint requests: Giuseppe Querques, MD, PhD, Department of Ophthalmology, University Vita-Salute, Ospedale San Raffaele, Via Olgettina 60, Milan, 20132, Italy; e-mail:

None of the authors have any conflicting interests to disclose.

© 2016 by Ophthalmic Communications Society, Inc.