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RETINAL ANGIOMATOUS PROLIFERATION DIAGNOSIS

A Multiimaging Approach

Ravera, Vittoria MD; Bottoni, Ferdinando MD; Giani, Andrea MD; Cigada, Mario MD; Staurenghi, Giovanni MD

doi: 10.1097/IAE.0000000000001152
Original Study
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Purpose: To identify signs occurring more frequently in retinal angiomatous proliferation (RAP) lesions compared with other types of choroidal neovascularization (CNV) in age-related macular degeneration.

Methods: In this cross-sectional retrospective study, 30 patients were evaluated. These signs were correlated with the type of CNV: shunting of blood flow to the lesion by fluorescein angiography, late leakage by indocyanine green angiography, intraretinal cysts and retinal pigmented epithelium interruption along the retinal pigmented epithelium detachment with a hyperreflective oval area by spectral domain optical coherence tomography, and presence of reticular pseudodrusen by infrared light.

Results: Shunting of blood flow was found in 56% of RAP, whereas it was absent in 100% of other CNVs. Late leakage in indocyanine green angiography occurred in all RAP cases, while it was found in 7% of other CNVs. Intraretinal cysts were detected in 100% of RAP cases and in 14% of other CNVs. Retinal pigmented epithelium interruption along the retinal pigmented epithelium detachment was evident in 93% of RAP cases and in 15% of other CNVs. Reticular pseudodrusen were present in 87% of RAP cases and in 21% of other CNVs.

Conclusion: All the signs investigated were strongly associated to RAP lesions. A multimodal imaging approach may help differentiating subtypes of neovascularization.

Using a multiimaging approach to facilitate a proper differential diagnosis, the authors investigated signs occurring more frequently in retinal angiomatous proliferations compared with other types of choroidal neovascularization.

Eye Clinic, Department of Clinical Science “Luigi Sacco”, Luigi Sacco Hospital, University of Milan, Milan, Italy.

Reprint requests: Giovanni Staurenghi, MD, Eye Clinic, Department of Clinical Science “Luigi Sacco”, Luigi Sacco Hospital, University of Milan, via G.B.Grassi 74, Milan 20157, Italy; e-mail: giovanni.staurenghi@unimi.it

Presented in part at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, Orlando, FL, May 4–8, 2014.

None of the authors have any financial/conflicting interests to disclose.

© 2016 by Ophthalmic Communications Society, Inc.