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ANALYSIS OF THREE-DIMENSIONAL CHOROIDAL VOLUME WITH ENHANCED DEPTH IMAGING FINDINGS IN PATIENTS WITH BIRDSHOT RETINOCHOROIDOPATHY

Silpa-archa, Sukhum MD; Maleki, Arash MD; Roohipoor, Ramak MD; Preble, Janine M. MS; Foster, C. Stephen MD, FACS

doi: 10.1097/IAE.0000000000000969
Original Study
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Purpose: To describe changes in three-dimensional choroidal volume and thickness with full raster scans of enhanced depth imaging optical coherence tomography in patients with birdshot retinochoroidopathy.

Methods: This prospective case series collected spectral domain optical coherence tomography images with the enhanced depth imaging technique from eight eyes of eight patients with birdshot retinochoroidopathy including four active patients (four eyes) and four quiet patients (four eyes). Fifty scans of each patient were manually segmented before automated built-in calibration software was used.

Results: Of all active patients, there were no statistically significant differences in the total choroidal volume and mean central choroidal thickness between the active and inactive phase over 6 months of follow-up. Alterations in choroidal parameters were evident and consistent after amelioration of inflammation, whereas the retinal volume and thickness remained stable. Regarding the eight inactive eyes at 6 months, the mean total choroidal volume and mean central choroidal thickness were significantly less than historical controls (P = 0.03 and P < 0.001, respectively). Persistent suprachoroidal hyporeflective space in two patients was noted despite the fact that clinical inflammation completely subsided at 6 months.

Conclusion: Choroidal volume and thickness changes were consistent with inflammation in patients with birdshot retinochoroidopathy. Patients with inactive birdshot retinochoroidopathy have significant reduction in choroidal volume and thickness than do normal patients.

This study is the first to describe analytical changes in three-dimensional choroidal volume and thickness with full raster scans in patients with birdshot retinochoroidopathy. Alterations in choroidal parameters were evidently consistent after amelioration of inflammation. Patients with inactive disease have significant reduction in choroidal volume and thickness than do normal patients.

*Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts;

Ocular Immunology & Uveitis Foundation, Waltham, Massachusetts;

Department of Ophthalmology, Faculty of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand;

§Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran; and

Harvard Medical School, Boston, Massachusetts.

Reprint requests: Charles Stephen Foster, MD, FACS, Massachusetts Eye Research and Surgery Institution, 1440 Main Street, Suite 201, Waltham, MA 02451; e-mail: sisukhum@gmail.com

None of the authors have any financial/conflicting interests to disclose.

© 2016 by Ophthalmic Communications Society, Inc.