To investigate the sensitivity
of spectral domain optical coherence tomography
in distinguishing polypoidal choroidal vasculopathy
(PCV) from typical neovascular age-related macular degeneration
One hundred and eighty-eight eyes in 156 patients with active PCV or typical nAMD were enrolled prospectively. Three spectral domain optical coherence tomography
manifestations, pigment epithelium detachment, double-layer sign, and thumb-like polyps were estimated in all the eyes. A diagnostic test to differentiate PCV from nAMD based on spectral domain optical coherence tomography
was performed. Furthermore, the sensitivity
was validated in a retrospective series of patients.
Pigment epithelium detachment, double-layer sign, and thumb-like polyps were more common in PCV eyes than in nAMD eyes. When the cutoff point was set as at least 2 positive signs out of 3 in the diagnostic test, the sensitivity
was 89.4% and specificity
was 85.3%. The results of the validation test further confirmed the strategy, with satisfying sensitivity
(87.5%) and specificity
Spectral domain optical coherence tomography
is sensitive and specific in distinguishing PCV from nAMD. From these results, the presence of at least two out three signs (pigment epithelium detachment, double-layer sign, and thumb-like polyps) indicates a positive test and is therefore suggested to be the screening strategy for PCV.