To evaluate the area of the foveal avascular zone (FAZ) detected by en face OCTA (AngioVue, Avanti OCT; Optovue) in healthy and diabetic eyes.
Retrospective chart review of patients who underwent fundus examination including en face OCTA. Eyes with proliferative diabetic retinopathy and history of laser photocoagulation were excluded. The FAZ area in the superficial and deep plexus layers were measured and evaluated using ImageJ software.
The FAZ area in the superficial layer was 0.25 ± 0.06 mm2 in healthy eyes (n = 19), whereas it was 0.37 ± 0.07 mm2 in diabetic eyes without retinopathy (n = 24) and 0.38 ± 0.11 mm2 in eyes with diabetic retinopathy (n = 20). Diabetic eyes showed statistically significant FAZ enlargement compared with healthy eyes, regardless of the presence of retinopathy (P < 0.01). The FAZ area in the deep plexus layer was also significantly larger in diabetic eyes than in healthy eyes (P < 0.01).
Our data suggest that diabetic eyes show retinal microcirculation impairment in the macula even before retinopathy develops. En face OCTA is a useful noninvasive screening tool for detecting early microcirculatory disturbance in patients with diabetes.
En face optical coherence tomography angiography (OCTA) revealed that eyes with and without diabetic retinopathy showed significant enlargement of the foveal avascular zone area when compared with healthy eyes (P < 0.01). En face OCTA is a useful noninvasive screening technique for detecting early microcirculatory disturbance in patients with diabetes.
*Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; and
†Ozeki Eye Clinic, Kanie, Japan.
Reprint requests: Miho Nozaki, MD, PhD, Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan; e-mail: email@example.com
None of the authors have any financial/conflicting interests to disclose.