To compare clinical outcomes after full-fluence
and half-fluence photodynamic therapy
(PDT) in chronic central serous chorioretinopathy
, focusing on changes in subfoveal choroidal thickness
(SFCT) using enhanced depth imaging optical coherence tomography.
Retrospective, comparative interventional case series.
In the full-fluence
(n = 25) and half-fluence
groups (n = 43), SFCT decreased from 351 ± 70 μ
m and 362 ± 63 μ
m at baseline to 276 ± 65 μ
m and 322 ± 70 μ
m at 3 months and remained at 267 ± 66 μ
m and 318 ± 76 μ
m at 12 months, respectively (all P
< 0.001, for each comparison with baseline). The change in SFCT was greater in the full-fluence
group than in the half-fluence
= 0.001). In the half-fluence
group, SFCT was thicker in the treated eye than in the fellow eye (P
= 0.045), whereas in the full-fluence
group, the difference in SFCT was not significant (P
= 0.209). Best-corrected visual acuity and central retinal thickness improved after PDT in both groups (all P
< 0.001). However, the differences between the groups were not significant (P
= 0.873 and P
= 0.124, respectively).
The results at 1 year show that full-fluence
PDT reduces SFCT more than half-fluence
PDT, and that SFCT after half-fluence
PDT was still thicker than that in the fellow eye. The clinical implications of this finding for long-term outcomes including recurrence rate remain to be elucidated.