Original StudyMULTIMODAL IMAGING FINDINGS AND MULTIMODAL VISION TESTING IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATIONSato, Taku MD*,†; Suzuki, Mihoko MD*,†; Ooto, Sotaro MD*,†; Spaide, Richard F. MD*,†Author Information *Vitreous-Retina-Macula Consultants of New York, New York, New York; and †LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York. Reprint requests: Richard F. Spaide, MD, Vitreous Retina Macula Consultants of New York, 460 Park Avenue, Fifth Floor, New York, NY 10022; e-mail: firstname.lastname@example.org Suppported by the LuEsther T. Mertz Retinal Research Foundation. T. Sato, S. Ooto, and M. Suzuki were funded by grants for fellowship study in the United States from Alcon Japan Ltd. R. F. Spaide receives consultant and royalty payments from Topcon Inc. None of the other authors have any conflicting interests to disclose. Retina: July 2015 - Volume 35 - Issue 7 - p 1292-1302 doi: 10.1097/IAE.0000000000000505 Buy Metrics AbstractIn Brief Purpose: To investigate the interactions among multimodal imaging findings and multimodal vision testing in neovascular age-related macular degeneration. Methods: Patients enrolled in a prospective study of neovascular age-related macular degeneration with at least 3 previous intravitreal anti-vascular endothelial growth factor injections. Each patient underwent multimodal fundus imaging including spectral domain optical coherence tomography and fundus autofluorescence, and multimodal vision testing, including visual acuity, contrast sensitivity, reading speed, and microperimetry. Results: There were 73 eyes of 49 consecutive patients enrolled. Generalized estimating equations' modelling showed that the significant independent predictors of visual acuity were the area of confluent hypoautofluorescence and involvement of the foveal center with either granular or confluent hypoautofluorescence (P < 0.001). Contrast sensitivity was negatively correlated with the area of confluent hypoautofluorescence (P < 0.001), involvement of the foveal center with granular hypoautofluorescence (P = 0.017), and subfoveal choroidal thickness (P = 0.042). The only significant predictor of reading speed was the size of confluent hypoautofluorescence (P < 0.001). The size of the defect in the ellipsoid zone (P < 0.001) and the presence of intraretinal fluid (P = 0.045) were correlated with microperimetry score. Conclusion: Confluent absence of autofluorescence was a highly significant predictor of vision testing and serves as an easy parameter to obtain in patients with neovascular age-related macular degeneration. This prospective study to correlate multimodal imaging with multimodal vision testing showed that confluent absence of autofluorescence was a highly significant predictor of several modalities of vision testing in neovascular age-related macular degeneration with at least 3 previous intravitreal anti-vascular endothelial growth factor injections. © 2015 by Ophthalmic Communications Society, Inc.