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Ahluwalia, Jasmina MD*; Rao, Sandeep MD*; Varma, Subhash MD; Gupta, Amod MS; Bose, Sunil MSc*; Masih, Joseph MSc*; Das, Reena MD, DNB*; Kumar, Narender MD*; Naseem, Shano MD*; Sharma, Prashant MD, DM*; Sachdeva, Man Updesh Singh MD*; Varma, Neelam MD*

doi: 10.1097/IAE.0000000000000366
Original Study

Purpose: To study the thrombotic factors, namely deficiencies of plasma proteins C, S, and antithrombin, factor V Leiden mutation, and positivity for antiphospholipid antibodies in young patients with retinal vein occlusion.

Methods: The thrombophilia parameters listed above were analyzed from the laboratory records of 50 patients with the clinical diagnosis of retinal vein occlusion, aged less than 50 years.

Results: A single prothrombotic factor was seen in 2 (4%) cases. The highest positivity was for the antiphospholipid antibodies (lupus anticoagulant in 6%, anticardiolipin antibodies in 2%, and anti-β 2 glycoprotein 1 in 10% cases). Other than one case where antiphospholipid syndrome was confirmed, these were transient. One patient had antithrombin deficiency. Protein C and protein S deficiency and factor V Leiden mutation were not seen in this group.

Conclusion: Our data suggest that these thrombophilia risk factors are not commonly associated with retinal vein occlusion, and there is a need for studies on other factors that contribute to the development of this condition.

Antiphospholipid antibody syndrome and antithrombin deficiency were rare in patients with retinal vein occlusion. Factor V Leiden mutation and protein C and S deficiency were not seen in a cohort of 50 patients aged less than 50 years with retinal vein occlusion from North India.

Departments of *Hematology and

Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India; and

Department of Ophthalmology, Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Reprint requests: Jasmina Ahluwalia, MD, Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India; e-mail:

None of the authors have any financial/conflicting interests to disclose.

© 2015 by Ophthalmic Communications Society, Inc.