Original StudyOPTICAL COHERENCE TOMOGRAPHIC REFLECTIVITY OF CYSTOID SPACES IS RELATED TO RECURRENT DIABETIC MACULAR EDEMA AFTER TRIAMCINOLONEHorii, Takahiro MD, PhD; Murakami, Tomoaki MD, PhD; Akagi, Tadamichi MD, PhD; Uji, Akihito MD, PhD; Ueda-Arakawa, Naoko MD; Nishijima, Kazuaki MD, PhD; Yoshimura, Nagahisa MD, PhD Author Information Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Reprint requests: Tomoaki Murakami, MD, PhD, Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaracho, Sakyo, Kyoto 606-8507, Japan; e-mail: [email protected] None of the authors have any financial/conflicting interests to disclose. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.retinajournal.com). Retina 35(2):p 264-271, February 2015. | DOI: 10.1097/IAE.0000000000000282 Buy SDC Metrics AbstractIn Brief Purpose: To determine the association between reflectivity levels in foveal cystoid spaces on optical coherence tomography images and the course of the logarithm of the minimum angle of resolution (logMAR) after triamcinolone acetonide treatment for diabetic macular edema. Methods: We retrospectively reviewed 58 consecutive eyes treated with an intravitreal or sub-Tenon's injection of triamcinolone acetonide for diabetic macular edema. The foveal cystoid spaces within central 1 mm were circumscribed, followed by measurement of optical coherence tomography reflectivity. The correlation between the reflectivity and visual outcome was investigated. Results: The optical coherence tomography reflectivity levels in foveal cystoid spaces increased at 1 month after treatment, but not at 3 months or 6 months. The preoperative reflectivity levels were correlated negatively with logMAR changes from 1 month to 6 months and from 3 months to 6 months but not with logMAR at individual time points compared with the preoperative logMAR. The changes in foveal thickness from 1 month to 6 months were correlated negatively with the baseline reflectivity and positively with logMAR changes from 1 month to 6 months and from 3 months to 6 months. Conclusion: Lower optical coherence tomography reflectivity in foveal cystoid spaces was associated with the rebound in macular thickening and visual deterioration after triamcinolone acetonide treatment for diabetic macular edema. Preoperative optical coherence tomographic reflectivity in the foveal cystoid spaces was negatively correlated to the recurrent macular thickening and visual deterioration after triamcinolone treatment for diabetic macular edema, whereas visual acuity or macular thickness at baseline did not predict the rebound of visual deterioration. © 2015 by Ophthalmic Communications Society, Inc.