Institutional members access full text with Ovid®

Share this article on:


Sonoda, Shozo MD, PhD; Sakamoto, Taiji MD, PhD; Yamashita, Takehiro MD, PhD; Shirasawa, Makoto MD; Otsuka, Hiroki MD, PhD; Sonoda, Yasushi MD, PhD

doi: 10.1097/IAE.0b013e3182a48917
Original Study

Purpose: To determine the relationship between the retinal morphologic changes and concentrations of intravitreal cytokines in eyes with diabetic macular edema.

Methods: A retrospective comparative study was performed. The preoperative optical coherence tomography images were evaluated to determine the presence of serous retinal detachments (SRDs), retinal cystic changes, and retinal swelling. The concentrations of vascular endothelial growth factor, interleukin (IL)-6, and IL-8 in vitreous samples collected during vitrectomy were determined. The correlations between optical coherence tomography parameters, other clinical factors, and the concentration of cytokines were calculated.

Results: Fifty-two eyes (52 patients) were investigated. An SRD was found in 19 of the 52 eyes (36.5%). Multivariate regression analysis showed that IL-6 was the only factor significantly associated with the presence of an SRD (P = 0.001; odds ratio, 1.268; 95% confidence interval, 1.105–1.452). The other morphologic changes, such as retinal cystic changes and retinal swellings, were not significantly associated with the concentrations of intravitreal cytokines.

Conclusion: The significant association of SRD with intravitreal IL-6 indicates that inflammation may play an important role in the development of SRD in diabetic macular edema.

Supplemental Digital Content is Available in the Text.The level of intravitreal interleukin-6 was significantly associated with the serous retinal detachment detected by optical coherence tomography in eyes with diabetic macular edema indicating its important role in the edema. This is partly supported by steroids being more effective than the anti–vascular endothelial growth factor drug. A serous retinal detachment may be important in determining the type of treatment.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Reprint requests: Taiji Sakamoto, MD, PhD, Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520 Japan; e-mail:

Supported by a grant from the Research Committee on Chorioretinal Degeneration and Optic Atrophy, Ministry of Health, Labor, and Welfare, Tokyo, Japan; and by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of the Japanese Government. The sponsor or funding organization had no role in the design or conduct of this research.

None of the authors have any conflicting interests to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

© 2014 by Ophthalmic Communications Society, Inc.