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Kim, Chang-Sik MD*,†; Shin, Kyung-Sup MD*; Lee, Haeng-Jin MD*; Jo, Young-Joon MD*,†; Kim, Jung-Yeul MD*,†

doi: 10.1097/IAE.0b013e3182a2e746
Original Study

Purpose: To analyze longitudinal changes in the retinal nerve fiber layer (RNFL) thickness in branch retinal vein occlusion (BRVO) using optical coherence tomography.

Methods: The authors prospectively analyzed 20 eyes in 20 patients diagnosed with branch retinal vein occlusion (BRVO) and followed for more than 1 year. The RNFL thickness of the normal and occluded eyes was measured at the time of diagnosis and at 1, 3, 6, and 12 months. The authors compared the changes in the occluded eye over the follow-up and the differences between two eyes at each time. They also analyzed the area opposite the occluded area.

Results: The thickness of the RNFL in BRVO was significantly reduced at 1, 3, 6, and 12 months (P = 0.005 at 1 month and P = 0.001 at 3, 6, and 12 months) compared with initial thickness. The RNFL thickness at 3 months did not differ significantly between 2 eyes, whereas at 6 months and 12 months, significant (P = 0.032, P = 0.002, respectively.) thinning was observed in the occluded eye. Analysis of the area opposite that of BRVO revealed no significant (P > 0.05) change during the follow-up and no difference between the 2 eyes.

Conclusion: There was a significant decrease in RNFL thickness over time in BRVO and significant thinning at 6 months compared with the normal eye. Retinal nerve fiber layer thinning needs to be differentiated from glaucoma or systemic disease, but it should be considered the natural course after BRVO.

The retinal nerve fiber layer thickness is decreased in branch retinal vein occlusion over time. So, it should be differentiated with glaucoma and other diseases because the branch retinal vein occlusion itself could cause the decrease of retinal nerve fiber layer thickness.

*Department of Ophthalmology, and

Research Institute for Medical Science, Chungnam National University College of Medicine, Daejeon, Korea.

Reprint requests: Jung-Yeul Kim, MD, Department of Ophthalmology, Chungnam National University Hospital, #640 Daesa-dong, Jung-gu, Daejeon 301-721, Korea; e-mail:

None of the authors have any financial/conflicting interests to disclose.

© 2014 by Ophthalmic Communications Society, Inc.