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Igbre, Ann O. MD, MPH*; Rico, Mario C. MD; Garg, Sunir J. MD

doi: 10.1097/IAE.0b013e31829f73bd
Original Study

Purpose: To evaluate the high-speed anterior segment optical coherence tomography (AS-OCT) grading of the AS inflammation in patients with ocular inflammation.

Methods: A retrospective consecutive case series study. Patients with clinically visible AS inflammation in at least one eye underwent AS-OCT (Visante; Zeiss Meditec) with three to eight line scans per eye, performed by a trained masked examiner. The images were reviewed for hyperreflective spots, noise, and artifact, and these were correlated to clinical examination.

Results: Seventy-eight eyes of 41 patients were imaged. Forty-seven eyes had anterior chamber cells on clinical examination, and 68 had hyperreflective spots visible on AS-OCT. There was a significant correlation (Spearman r = 0.7274) between clinical examination and Visante OCT images. Several patterns of inflammation and artifacts were apparent.

Conclusion: The AS-OCT is a promising technique for grading anterior chamber cells. There was a significant correlation between clinical examination and Visante grading.

In this study, automated grading of the inflammation of the anterior chamber significantly correlates to the Standardization of Uveitis Nomenclature grading system. Anterior segment optical coherence tomography is a promising technique for grading anterior chamber inflammatory cells.

*Department of Ophthalmology, and

Sol Sherry Thrombosis Center, Temple University School of Medicine, Philadelphia, Pennsylvania; and

MidAtlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Reprint requests: Sunir J. Garg, MD, MidAtlantic Retina, The Retina Service of Wills Eye Institute, Thomas Jefferson University, 840 Walnut Street, Suite 1020, Philadelphia, PA 19107; e-mail:

Supported by the J. Arch McNamara Fund for Retina Research (A.O.I. and S.J.G.) and the NIH-NHLBI, K01 HL103197 (M.C.R.).

Author Contributions: Designing and conducting the study (S.J.G.); Management, analysis and interpretation of the data, preparation and review of the study (A.O.I, M.C.R, S.J.G).

None of the authors have any financial/conflicting interests to disclose.

A retrospective IRB approval was obtained from Wills Eye Institute.

© 2014 by Ophthalmic Communications Society, Inc.