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RETCAM FLUORESCEIN GONIOANGIOGRAPHY: A New Modality for Early Detection of Angle Neovascularization in Diabetic Retinopathy

Azad, Rajvardhan MD; Arora, Tarun MD; Sihota, Ramanjit MD; Chandra, Parijat MD; Mahajan, Deepankur MD; Sain, Siddarth MD; Sharma, YogRaj MD

doi: 10.1097/IAE.0b013e318285cdd6
Original Study

Purpose: To evaluate the role of Retcam fluorescein gonioangiography in detecting neovascularization of the angle and correlate the same with gonioscopy in diabetic retinopathy.

Methods: One hundred and fifty eyes of 150 patients (25 each of mild, moderate, severe, very severe nonproliferative diabetic retinopathy (NPDR) proliferative diabetic retinopathy (PDR); and PDR with high-risk characteristics) were recruited. They underwent complete ocular examination including applanation tonometry, gonioscopy, Retcam fluorescein gonioangiography, and fundus fluorescein angiography.

Results: Using Retcam fluorescein gonioangiography, of 150 eyes neovascularization of the angle was detected in 37 eyes (24.66%) compared with 22 eyes (14.66%) on gonioscopy (P = 0.04). Small newly formed vessels were evident only with Retcam fluorescein gonioangiography. In 10 of 50 patients (20%) with severe/very severe NPDR, angle neovascularization was appreciable on Retcam fluorescein angiography compared with 5 patients (10%) on gonioscopy. Similarly, 25 of 50 patients (50%) with PDR/PDR with high-risk characteristics had neovascularization of the angle on Retcam gonioangiography compared with 17 (34%) on gonioscopy.

Conclusion: Retcam fluorescein gonioangiography is a novel technique for early detection of angle neovascularization in diabetic retinopathy and hence preventing progression to neovascular glaucoma. The objective nature of this test helps in precise decision making compared with gonioscopy for early intervention especially in cases of pre-PDR.

Gonioscopy is a quick and inexpensive investigation for detecting neovascularization of the angle in clinical practice, but the inherent problems of subjectivity and low sensitivity of this test cannot be overlooked. Retcam with its fluorescein angiography module provides a novel technique to bring objectivity and high sensitivity to the detection of the same and adds to our armamentarium in the management of diabetic retinopathy.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Reprint requests: Tarun Arora, MD, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Room No. 486, 4th Floor, New Delhi 110029, India; e-mail:

The authors have no conflict of interest to disclose.

© 2013 by Ophthalmic Communications Society, Inc.