The authors analyzed the relationship between the integrity of the outer limiting membrane (OLM) and the presence of inner retinal cavitation and photoreceptor disruption in eyes with macular telangiectasia Type 2 (MacTel Type 2).
Cirrus optical coherence tomography images were analyzed with attention to the presence or absence of inner and outer retinal cavities, photoreceptor loss, or disruption and OLM integrity.
Ninety-seven eyes with MacTel Type 2 that were suitable for analysis were identified. The OLM was intact in all 48 eyes with inner retinal cavities without photoreceptor disruption. By contrast, the OLM was absent or disrupted in 8 of 10 eyes with photoreceptor disruption.
If Müller cell disruption contributes to inner retinal cavitation, it does not appear to affect the OLM, which is the only part of the Müller cell that is visible clinically. By contrast, the integrity of both the OLM and photoreceptors appear to be closely linked in MacTel Type 2. This observation is consistent with the hypothesis that Müller cell dysfunction plays a role in the pathogenesis of MacTel.
The authors report that the outer limiting membrane is disrupted in eyes with macular telangiectasia type 2 when photoreceptors are disrupted but not in the presence of inner retinal cavitation.
*Discipline of Clinical Ophthalmology and Eye Health, Save Sight Institute, The University of Sydney, Sydney, Australia
†Lions NSW Eye Bank, NSW Organ and Tissue Donation Service, Sydney and Sydney Eye Hospital, Sydney, Australia.
Reprint requests: Dr. Matthew Krilis, MBBS, Save Sight Institute, Campus of Sydney and Sydney Eye Hospitals, 8 Macquarie Street, Sydney, New South Wales, Australia 2001; e-mail: firstname.lastname@example.org
Supported by the Lowy Medical Research Institute.
Presented at the Royal Australasian College of Ophthalmology (RANZCO) Annual Scientific Meeting, Canberra, Australia, November 2011.
The authors have no conflict of interest to disclose.