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Lombardo, Marco MD, PhD*; Lombardo, Giuseppe MEng, PhD†,‡; Lomoriello, Domenico Schiano MD*; Ducoli, Pietro MD*; Stirpe, Mario MD*; Serrao, Sebastiano MD, PhD*

doi: 10.1097/IAE.0b013e3182807642
Original Study

Purpose: To investigate the variation and symmetry of cone density distribution along the nasal and temporal retina of fellow eyes.

Methods: An adaptive optics retinal camera (rtx1; Imagine Eyes) was used to obtain images of the parafoveal cone mosaic in 20 healthy subjects. Cone density was estimated at 250, 420, 760, and 1,300 μm eccentricity from the fovea along the nasal and temporal retina of both eyes in each subject. The coefficient of variation and the intraclass correlation coefficient were used to calculate the variation and absolute agreement of cone density between the same retinal eccentricity locations of fellow eyes, respectively.

Results: A considerable variation of cone density between subjects was found at all eccentricities along the nasal and temporal retina (intersubject coefficient of variation ≥ 11%, P < 0.001). The intrasubject variation of cone density was, however, moderate (coefficient of variation ≤ 13% in 95% of the subjects); a high agreement was, on average, found between the cone density estimates at the same eccentricity along the nasal and temporal retina of fellow eyes (intraclass correlation coefficient ≥ 0.86, P < 0.001).

Conclusion: Cone density follows a symmetrical distribution between fellow eyes. A systematic distribution of parafoveal cones between fellow eyes may provide an anatomical basis for the involvement of the photoreceptor layer in the first step of binocular spatial sampling.

The authors found a high agreement of parafoveal cone density between the same eccentricity locations along the nasal and temporal retina of fellow eyes in a population of healthy subjects using an adaptive optics retinal camera.

*Fondazione G.B. Bietti IRCCS, Rome, Italy

CNR-IPCF Unit of Support Cosenza, University of Calabria, Rende, Italy

Vision Engineering, Rome, Italy.

Reprint requests: Marco Lombardo, MD, PhD, Fondazione G.B. Bietti IRCCS, Via Livenza 3, 00198 Rome, Italy; e-mail:

None of the authors have any financial/conflicting interests to disclose.

© 2013 by Ophthalmic Communications Society, Inc.