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LONG-TERM FOLLOW-UP OF ACUTE ZONAL OCCULT OUTER RETINOPATHY

Hoang, Quan V. MD, PhD*,†,‡; Gallego-Pinazo, Roberto MD*,†,§; Yannuzzi, Lawrence A. MD*,†,‡

doi: 10.1097/IAE.0b013e318286cc57
Original Study
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Background: Acute zonal occult outer retinopathy (AZOOR) was described by Gass in 1992 as an independent posterior uveitis characterized by photopsias and rapid visual field zonal loss, with 70% of cases stabilizing within 6 months, although there is a paucity of long-term documentation of AZOOR cases.

Methods: The authors reported the case of a 55-year-old woman diagnosed with AZOOR and followed for 13 years.

Results: Best-corrected visual acuity at baseline was 20/60 in her right eye and 20/25 in her left eye, with an annular peripapillary area of irregular retinal thickening and temporal visual field loss in both eyes. Over her 13-year follow-up, best-corrected visual acuity dropped to 20/60 in both eyes and visual field loss because of chorioretinal atrophy progressed significantly. Antiviral and immunomodulatory drugs did not halt this progression.

Conclusion: The prognosis of cases with AZOOR should be cautiously considered. The authors showed that in the long term, chorioretinal atrophy may lead to severe visual field loss in patients with AZOOR.

The authors described a patient who presented with findings consistent with acute zonal occult outer retinopathy who was followed for 13 years with progression of diffuse bilateral outer retinal atrophy.

*Vitreous, Retina, Macula Consultants of New York, New York, New York;

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York;

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York; and

§Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain.

Reprint requests: Lawrence A. Yannuzzi, MD, 460 Park Avenue, Fifth Floor, New York, NY 10022; e-mail: layannuzzi@gmail.com

Supported by the LuEsther T. Mertz Retina Research Center, Manhattan Eye, Ear, and Throat Hospital, and The Macula Foundation, Inc.

No authors have any conflicting interests to disclose.

© 2013 by Ophthalmic Communications Society, Inc.